Sentences with phrase «inducing immune tolerance»

Treatment of experimental arthritis by inducing immune tolerance with human adipose - derived mesenchymal stem cells.

Since the liver plays a key role in inducing immune tolerance, that protein increases the production of regulatory T cells, suppressing the immune system's attack on the body.

In this study, the researchers were able to block the autoimmune response by inducing immune tolerance to alpha - myosin.

Inducing immune tolerance in people who have developed inhibitors is one approach.

The findings, published online in Nature Communications on July 7, support inducing immune tolerance as a viable strategy to achieve life - long transplant survival.

If researchers can complete their 50 - year quest to induce immune tolerance safely and selectively, the prospects for hundreds of thousands of transplant recipients would be greatly improved, and so, too, might the prospects for controlling autoimmune diseases.

The latest study builds off of work Kawai and his colleagues began fourteen years ago, when they launched the first clinical trial that attempted to use bone marrow to induce immune tolerance for kidney recipients, to avoid the sometimes dangerous side effects of life - long immosuppressive therapy.

A key mechanism used by our body to induce immune tolerance is by induction of regulatory T (Treg) cells, a subset of white blood cell that orders other T cells to stand down.

Not exact matches

Klinman's finding adds to growing concerns about the risk of inducing tolerance by giving vaccines to newborns, who have immature immune systems.

Currently, the NIAID - supported Immune Tolerance Network is conducting a randomized trial called IMPACT to determine whether peanut OIT can lower the risk of allergic reactions, induce tolerance and change the immune responses of peanut - allergic children aged 12 to 4Tolerance Network is conducting a randomized trial called IMPACT to determine whether peanut OIT can lower the risk of allergic reactions, induce tolerance and change the immune responses of peanut - allergic children aged 12 to 4tolerance and change the immune responses of peanut - allergic children aged 12 to 48 months.

While difficult to achieve, immune tolerance — in which a transplanted organ is accepted without long - term immunosuppression — can be induced in some patients.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

The study participants were injected under the skin with different doses of GAD or a placebo preparation in order to induce immune system tolerance to the beta cells.

A number of studies reported that HDAC inhibitors could suppress the immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit immune rejection or induce tolerance in organ transplantation and BMT (20 — 23).

INTERPRETATION: We have developed a gene gun mediated Abeta42 gene vaccination method that is efficient to break host Abeta42 tolerance without using adjuvant and induces a Th2 immune response.

Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).