Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease -
inducing, insoluble
tangles of another protein,
tau].
The next step, he says, will be to use his team's three - dimensional «Alzheimer's in a dish» model to see whether microbes can
induce amyloid - beta plaques to form in human brain tissue, and then whether those plaques lead to
tau tangles and inflammation.