Sentences with phrase «infant microbiome composition»

Quiz Ref IDWe found that delivery mode was more strongly associated with infant microbiome composition than was diet at 6 weeks.

Not exact matches

We characterized the intestinal microbiome of 102 6 - week - old infants and observed independent associations between stool microbial community composition, mode of delivery, and feeding method.

Objective To examine the associations of delivery mode and feeding method with infant intestinal microbiome composition at approximately 6 weeks of life.

Overall stool microbiome community composition was characterized using generalized UniFrac analysis.30 Controlling for the effects of feeding method, delivery mode was strongly associated with infant gut microbiome composition (P <.001; Q <.001)(Figure 1A).

We evaluated the associations between the composition of the 6 - week intestinal microbiome and both delivery mode and feeding method in 102 full - term, appropriately grown infants enrolled in the New Hampshire Birth Cohort Study.

To our knowledge, our study was the first to examine the contribution of delivery mode to infant intestinal microbiome composition in association with that of another important predictor of microbiome composition, infant diet.

Although a few previous studies have found associations between infant feeding and intestinal microbiome composition,9 - 12, 14 to our knowledge, none has examined the relative contribution of combination feeding (breast milk and formula) alongside exclusive formula or breastfeeding to overall microbial community composition.

An emerging body of literature in adults has begun to establish clear associations between gut microbiome composition and a wide range of health outcomes.1 - 6 In contrast, comparatively little is known about the gut microbiome in infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequences.

Importance The intestinal microbiome plays a critical role in infant development, and delivery mode and feeding method (breast milk vs formula) are determinants of its composition.

In a previous study of 24 healthy women, vaginal microbiome composition became less diverse between the second and third trimesters of pregnancy and just before delivery was enriched with Lactobacillus species, likely contributing to vertical transmission of these bacteria during vaginal birth.21 In a study of 10 newborns in Venezuela, within hours of delivery, the intestinal tracts of infants born vaginally were colonized by Lactobacillus and Prevotella, whereas infants delivered operatively acquired bacteria present on the mother's skin and the hospital environment, such as Staphylococcus, Proprionibacterium, and Corynebacterium.15 Quiz Ref ID Our findings, based on a large group of 6 - week - old infants, indicated that Lactobacillus also contributes to the microbial environment of the gut but to a lesser extent than Bifidobacteria, Bacteroides, and Streptococcus.

We observed significant independent associations between the composition of the infant gut microbiome and both delivery mode and feeding method.

Rather, it conveys the subtle and elegant choreography of one part of the human microbiome: The relationships between the mothers» genetics, the composition of her breast milk and the development of her infant's gut microbiota.