Sentences with phrase «infants with microcephaly»

The central nervous system damage seen with prenatal ZIKV infection is likely due to direct cellular injury, as ZIKV RNA15, 17,32 and live virus15 have been identified in the brain tissue of infants with microcephaly.

To evaluate the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil.

Objective To evaluate the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil.

The 3 largest case series of infants with microcephaly also reporting congenital contractures found that, among 35, 48, and 52 infants with microcephaly and presumed congenital ZIKV infection, isolated clubfoot occurred in 14 %, 10.4 %, and 3.8 % and arthrogryposis in 11 %, 10.4 %, and 5.7 %, respectively.36 - 38 Among a series of 104 infants under clinical investigation, 7 (6.7 %) with presumed (5 infants) and laboratory - confirmed (2 infants) congenital ZIKV infection had arthrogryposis; 6 of these infants had a head circumference of at least 2 SD below the mean.41 All had bilateral congenital hip dislocation, which previously has been reported to occur in 30 % to 40 % of children with arthrogryposis of various etiologies and 3 of 7 had dislocation or partial dislocation of 1 or both knees.41, 57

A 2006 study of 77 pregnant women infected with West Nile virus reported that two had infants with microcephaly, the birth defect lately associated with Zika that results in unusually small and damaged brains.

In a study conducted in Brazil, 70 infants with microcephaly were examined at CAVIVER, a nongovernmental organization clinic and referral center dedicated to visually disabled children in Fortaleza.

Not exact matches

There's still a lot that we don't know about Zika, including whether or not it's definitively the cause of infants being born with microcephaly or other neurological problems.

Mothers and families of infants born with congenital anomalies (e.g. microcephaly) should be supported to breastfeed their infants in line with WHO recommendations.

As most studies have only carefully examined infants with presumed or confirmed congenital ZIKV infection who have microcephaly, more studies are needed to understand ocular findings in those infants with congenital ZIKV infection without microcephaly.

Stella Guerra performs physical therapy on an infant born with microcephaly in Recife, Brazil.

Other infections also can cause microcephaly; in fact, out of 121 infants tested for other pathogens, 26 had evidence of infection with either toxoplasmosis, herpes simplex, cytomegalovirus, and syphilis.

An association between Zika infections during pregnancy and the birth of babies with microcephaly (a birth defect in which an infant's brain does not develop properly resulting in a smaller than normal head) was first suggested by Brazilian physicians in August 2015, and in November microcephaly cases potentially associated with Zika started to be recorded; three months later WHO made its announcement.

The infection has been linked to microcephaly, a condition in which infants are born with unusually small heads and brain damage.

The disease has also been confirmed to cause microcephaly in more than 2,700 infants born to women infected with the virus while pregnant.

Even as the Zika virus becomes more prevalent — the Centers for Disease Control reports that the number of U.S. infants born with microcephaly and other birth defects is 20 times over the normal rate — researchers are still trying to fully pin down the identifying consequences of the viral infection.

We next estimated the maximum number of births potentially affected by ZIKV in Latin America, as this region is the focus of the recent outbreak and the first to point to a possible association with microcephaly in newborn infants to mothers infected with ZIKV.

Petersen's remarks were among the strongest suggestions yet from a top CDC scientist that Zika infection during pregnancy can — at least in some cases — cause microcephaly, a condition in which infants are born with abnormally small heads and possibly brain damage.

Although most infants had microcephaly by head circumference measure, some patients had a measurement that was consistent with their gestational age, as brain atrophy was compensated by an enlargement in ventricular size.19

The main birth defect attributed to Zika is microcephaly, a rare neurological condition in which an infant is born with a much smaller head — an effect of abnormal brain development.

The rate of infants and fetuses who had microcephaly in Colombia from 2015 to the end of 2016 is shown with a dotted line.

In the recent case series, most infants with probable congenital ZIKV infection were noted to have craniofacial disproportion (95.8 %) and, to a lesser degree, biparietal depression (83.3 %), prominent occiput (75 %), and excess nuchal skin (47.9 %).38 Features supportive of the FBDS phenotype scattered through published reports include redundant scalp, 27,36,39,41 occipital prominence and / or overlapping sutures,14,20,22 - 24, 26,27,38 and typical craniofacial appearance with disproportion.13, 27,33,34,40 The FBDS phenotype is also prevalent in ZIKV - related media.47 Among infants with severe microcephaly, the pattern appears to be consistent, although the degree of cranial vault deformation varies.

Structural eye anomalies (in particular, microphthalmia and coloboma), cataracts, intraocular calcifications, and posterior ocular findings have been reported in infants with presumed and laboratory - confirmed prenatal ZIKV infection; however, posterior findings have been the most prevalent.21,25,28,33,35,36,41 - 43 Case series report chorioretinal atrophy, focal pigmentary mottling of the retina, and optic nerve atrophy / anomalies.28, 34,37,41 - 43,55 Series of 20 or more infants with presumed ZIKV - associated microcephaly report ocular findings in 24 % to 55 %.28, 33,42 In one study, testing for ZIKV IgM was performed in 24 of 40 infants (60 %) with microcephaly and the results were positive in the cerebrospinal fluid in 100 % of those tested.42 The proportion of infants with ocular lesions did not differ in those with and without testing.42 In that series, first trimester maternal infection and smaller head circumference significantly correlated with the presence of abnormal ocular findings.42

Contracted through the bite of an infected mosquito or through sexual or other modes of transmission, Zika virus (ZIKV) infection can be prenatally passed from mother to fetus.1 The virus was first identified in the region of the Americas in early 2015, when local transmission was reported in Brazil.2 Six months later, a notable increase in the number of infants with congenital microcephaly was observed in northeast Brazil.3, 4 Clinical, epidemiologic, and laboratory evidence led investigators to conclude that intrauterine ZIKV infection was a cause of microcephaly and serious brain anomalies.5 - 7 However, as with other newly recognized teratogens, these features likely represent a portion of a broader spectrum.

The FBDS phenotype has been reported in an infant with laboratory - confirmed ZIKV infection, 13 in a neuroimaging report documenting cranial bone collapse in infants born to mothers with suspected ZIKV infection during pregnancy, 14 and a recent case series of infants with probable ZIKV - associated microcephaly.38 In 3 of the largest case series reporting 35, 48, and 104 infants primarily with suspected congenital ZIKV infection, 33,37,38 approximately two - thirds of infants had severe microcephaly.

Eighty - five percent of the fetuses or infants with potentially Zika - associated birth defects in this report had brain abnormalities or microcephaly, with most having both microcephaly and specific brain abnormalities.

A recent increase in the prevalence of microcephaly in newborn infants and vision - threatening findings in these infants is likely associated with the rapid spread of ZIKV.

The most devastating of these defects is microcephaly — when infants are born with abnormally small heads and underdeveloped brains.

In the analysis, Mariana Leal, of the Hospital Agamenon Magalhaes and the Federal University of Pernambuco in Brazil, and colleagues looked at 70 infants in Brazil who had been diagnosed with Zika - linked microcephaly.

One infant was born in the state with Zika - related microcephaly.