To assess whether CAMKK1 can improve cardiac tissue repair, the group overexpressed CAMKK1 in MSCs and injected the modified MSCs or their conditioned medium (CM) into
infarcted cardiac tissue at the time of AMI.
Not exact matches
GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the
infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards
cardiac tissues [47 - 49].
Specifically, application of a prefabricated
cardiac tissue patch to prevent dilation and to improve pumping efficiency of the
infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.