Sentences with phrase «infarcted myocardium»
Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.
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Given their ability to self - renew and differentiate, stem cells have been proposed to be excellent candidates to repopulate and regenerate the infarcted myocardium.
It has been demonstrated that MSCs injected into the infarcted myocardium significantly improve the left ventricular function and reduce the infarcted area size.