Sentences with phrase «infected cell surface»

The external face of the flavivirus NS1 protein (sugars in grey balls) is exposed on infected cell surfaces where it can interact with the immune system.

Not exact matches

Now, researchers at Washington University School of Medicine in St. Louis have shown, in mice, that the virus infects a rare type of intestinal cell called a tuft cell, so named because each cell sports a cluster of hairlike extensions on its surface.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

Robyn Biti, Graeme Stewart of Westmead Hospital in Sydney, Australia, and colleagues report that they have found an HIV - infected homosexual man whose white blood cells contain a defective copy of a critical surface protein, called CCR5, that the virus uses to gain entry into the cells.

The mushroom - shaped protein specializes in infecting cells, first by binding a trio of sites on its head to three separate sugar molecules on the surface of targeted cells.

Lee is an expert on the viral envelope, the dynamic outside surface of a virus that latches onto a cell, then changes its shape to let the virus enter and infect the cell.

Soares: Well the H and the N refer to two proteins on the virus surface that help it infect cells and also spread from cell to cell once they are in the lungs, in case of birds in the gut, as well.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

Questions the group hopes to answer over the next five years include if LRAs will promote the expression of viral protein on the surface of infected cells, and if pairing LRAs with immune interventions will lead to the clearance of persistent, latent infection.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

Hemagglutinin binds to glycan receptors found on the surface of respiratory cells, and the strength of that binding determines how effectively the virus can infect those cells.

Because HIV uses CD4 to infect cells, the researchers used a CAR molecule that hijacks the essential interaction between HIV and the cell surface molecule CD4 to make stem cell - derived T - cells target infected cells.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cells.

With gene - editing tools such as CRISPR, scientists can now eliminate immune - provoking sugars from the surface of pig cells, introduce human genes that regulate blood coagulation to prevent dangerous clots, and snip out viral sequences that some fear could infect a human host.

Last year, she and her colleagues showed that the therapy could also be used to help halt HIV by targeting one of several viral proteins on the surface of HIV - infected cells.

This migrates to the surface of infected cells and anchors them to the walls of capillaries near organs, including the brain.

Then, by placing surface proteins of each HCV virus onto these pseudoviruses, the researchers were able to efficiently infect human cells with the HCV strains in tissue culture.

Plasmodium parasites infect human red blood cells and gain entry via receptors on the cell surface.

CD74 is broken into products that fit into the groove of cell surface immune response proteins as part of the chain of events that activates T cells — immune cells that normally attack infected (or damaged) cells in the body.

A team of researchers from the Pasteur Institute in Paris has discovered a second receptor on the surface of cells that helps HIV to enter and infect them.

«Immune system cells protect against CMV - induced hearing loss in mice: Natural killer cells recognize and bind to viral protein on surface of infected inner ear cells.»

HIV infects white blood cells by sequentially attaching to two receptors on their surfaces.

She found a gene for what's known as the major histocompatibility complex (MHC)-- cell surface molecules that help the immune system recognize foreigners — that was remarkably similar to one in humans that allows infected people to keep the virus in check for decades.

Using their novel approach, the scientists were able to disable a protein on the T - cell surface called CXCR4, which can be exploited by HIV when the virus infects T cells and causes AIDS.

Normally, the red blood cell's surface is smooth and the cell is deformable, but when infected with a malaria parasite, small protein nodules called knobs form on the surface.

Breaches in these layers, which can be caused by physical trauma or some sexually transmitted diseases, allow HIV to bypass the protective surface to access immune cells that can be infected by HIV.

The gp160 is expressed on the surface of infected cells, an

Clone 1022 cells ezpress human CD4 protein on the cell surface and can be infected by most isolates of HIV.

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

Binds to gp120 on the surface of IIIB, SF2, MN, RF, and CC - infected cells.

These work by blocking the virus's surface protein neuraminidase, which allows budding virus particles to break away from infected cells.

A study from Dr. Dusty Miller's laboratory indicates that Jaagsiekte sheep retrovirus (JSRV) infects both sheep and human cells cultured outside the body and does so by attaching to a receptor on the surface of lung cells.

Activated, HIV - infected cells have altered cell - surface glycosylation patterns with respect to resting, uninfected cells.

This type of «killer» T cell responds to previously encountered cell - surface molecules — including the fragments of SIV proteins encoded by the genes in the CMV / SIV vaccine — and destroys SIV - infected cells.

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

From there they showed that cancer cells had lost structural polarity, resulting in random distribution of CAR receptors on their surface, thereby allowing the virus to attach to and infect the tumor cells.

To characterize the isolate that replicated in HeLa cells, a 166 - bp RNA sequence containing the variable region C of the envelope (Env) surface protein was PCR - amplified from infected HeLa cell tissue culture supernatants.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

Natural Killer cells patrol the body and detect characteristic alterations on the surface of cancer cells or virus - infected cells.

Corneal ulcer or irritation in pets, also called keratitis, occurs when cells covering the clear outer surface of the eye, the cornea, are irritated or become infected.