Sentences with phrase «infected human cells»

To do this, a team led by Matthew Weitzman of the University of Pennsylvania crosslinked the host factors of infected human cells with the DNA of adenovirus, herpes simplex virus and vaccinia virus.

Now, a novel computational method shows that a viral protein found in EBV - infected human cells may activate genes associated with increased risk for autoimmunity.

Rational engineering of enzymes with improved anti-HIV properties: We collaborate with experimental groups (Prof. Buchholz, TUD) in the generation of new DNA recombinases with improved properties to excise HIV from infected human cells.

To confirm these findings, the team infected human cells in dish with two forms of CMV — one of which could generate the IE2 accelerator circuit and one that could not.

Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells.

MiRNA - seq and mRNA - seq will be carried out from the same RNA sample thereby integrating the mRNA and miRNA «sequenomes» of infected human cells most relevant to human toxoplasmosis.

Prior research has shown that the dengue virus (DENV) protein NS1, which is secreted by infected human cells, is a likely culprit behind such leaks.

Following a single treatment with CRISPR / Cas9, viral fragments were successfully excised from latently infected human cells embedded in mouse tissues and organs.

Greber and his team infected human cells in culture with the chemically labeled viruses, and observed the behavior of the viral DNA during entry into cells.

Thirty years ago he engineered a bacterial strain to produce an HIV enzyme so he could study how it enables HIV to infect human cells.

An Australian research team, however, recently reached a milestone when it became the first to screen and catalogue all of the genes activated by a BSL4 pathogen when it infects human cells.

The protein, they found, preferentially binds to human endothelial cells, allowing the retrovirus, which would not normally infect human cells, to enter them.

«We had assumed that pig tissues were more safe than baboon tissues, but now we see they can infect human cells,» Allen says.

For the first time, scientists have discovered a pig retrovirus that infects human cells.

Newburg and his collaborators are also studying a human - milk fat that seems to inhibit HIB from infecting human cells, and yet another milk component that prevents hiv from disabling the host's immune cells.

Knowledge of this structure, called the cytoplasmic tail of gp41 protein, will help researchers further understand how the virus infects human cells and how progeny viruses are assembled and released from infected cells.

High used AAV to deliver the gene because the virus is considered benign; although it infects human cells, it is not known to cause any symptomatic infection.

In laboratory studies reported in the Proceedings of the National Academy of Sciences (PNAS), the researchers found that these «neutralizing» antibodies prevented a key part of the virus, known as MERS CoV, from attaching to protein receptors that allow the virus to infect human cells.

The research showed the beta - lactamase genes in Klebsiella pneumoniae were on all the time, whether or not the bacteria were infecting human cell cultures.

Then, by placing surface proteins of each HCV virus onto these pseudoviruses, the researchers were able to efficiently infect human cells with the HCV strains in tissue culture.

But even if XMRV is not a threat to human health, the fact that a retrovirus that can readily infect human cells was apparently generated by chance in the lab raises some interesting and potentially troubling issues.

For instance, the way Zika infects human cells and hijacks their machinery to copy itself many times has proved elusive.

The experiment's final product is equivalent to the naturally occurring genetic code of M. genitalium, with two minor exceptions: The scientists disabled the gene that gave the bug power to infect human cells, and they added a few «watermarks,» short strips of signature genetic code that identify the product as man - made.

Both kill upwards of a third of people infected and, like many viruses, emerged from animals — bats and camels in the case of MERS — after mutating into a form capable of infecting human cells.

MxA is thought to target influenza A by binding to the nucleoprotein that encapsulates the virus» genome, and mutations in this nucleoprotein have been linked to the virus» ability to infect human cells.

If AAV is exclusively used to infect human cells, it stably i

When other researchers studied the virus in patients with PML, they found a mutation in its protein shell, the part that allows it to bind to and infect human cells.

«Once it infects a human cell, the virus could interact with human enzymes to produce these small RNAs, which could in turn alter brain development and lead to microcephaly.»

The microcurrents of electricity prevent viruses from infecting human cells (this is what Kaali and Lyman discovered) which prevents the virus from hijacking the cell's» reproductive capacity and multiplying.

Not exact matches

«But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease.»

But when the researchers added higher concentrations of BX795 to cultured human corneal cells infected with HSV - 1, the infection was quickly cleared.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

The human immune system is adept at recognizing antigens it has met before: Antibodies snap onto the projecting viral proteins and prevent the organism from infecting other cells.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

«This raises important questions about whether human norovirus infects tuft cells and whether people who have chronic norovirus infections and continue to shed the virus long after infection do so because the virus remains hidden in tuft cells,» Wilen said.

Somewhere along the way, certain molecular changes, including a deletion of 29 base pairs from the original virus, allowed SARS to infect and replicate in human cells.

A study published last March shows that avian flu strains can infect cells lining the human respiratory system, but they seem to have difficulty replicating.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

We use viruses called phages that infect bacteria but not human cells.

Human cells infected by the viruses produced the gene products, giving T cells an advance exposure to them.

An unknown component of breast milk appears to kill HIV particles and virus - infected cells, as well as blocking HIV transmission in mice with a human immune system.

Human immunodeficiency virus - type 1 (HIV - 1) replicates actively in infected individuals, yet cells with intracellular depots of viral protein are observed only infrequently.

Human placental cell line Jeg - 3 can be readily infected by a circulating strain of Zika virus (left panel) and completely protected by treatment with nanchangmycin (right panel).

In the present study conducted at IDOR in conjunction with UFRJ, the research team observed that ZIKV infects human - derived iPS neural cells, neurospheres and cerebral organoids causing cell death, malformations and reducing growth by 40 %.

Confocal microscopy of human neural stem cell culture infected with Zika virus (red).

The mutated, drug resistant H7N9 virus, however, was still able to infect cultured human cells and spread between laboratory animals as efficiently as nonmutated strains, researchers report December 10 in Nature Communications.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

The two reports also showed that Zika virus infected and damaged neuronal stem cells harvested from mice and humans.

That's consistent with earlier in vitro findings that Zika can infect and damage human neural precursor cells.