Sentences with phrase «infected macaques»

In SIV - infected macaques, Picker's team found that a CMV - based vaccine cleared the virus in 50 % of the monkeys by eliciting and maintaining a powerful, but non-traditional, cytotoxic T - cell response.

We thus aimed to grow any persistent B. burgdorferi present in the heart tissue of our infected macaques within an isolated system exposed to a mammalian host environment.

To bridge this gap, I analyze Simian - HIV - infected macaques sampled spatially and temporally during drug resistance evolution.

Menin mediates Tat - induced neuronal apoptosis in brain frontal cortex of SIV - infected macaques and in Tat - treated cells.

Before Zika infection, the researchers collected dengue and yellow fever antibodies from blood samples taken from the previously infected macaques.

To study the pathogenesis of HIV - induced PNS disease, Jamie Dorsey, Research Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuropathy.

It has been known since 1960 that early doses of polio vaccine were widely contaminated with simian virus 40, or SV40, which infects macaque monkeys.

Negative controls including the secondary antibody alone and uninfected monkey tissue were used, as was an ex vivo section of infected macaque brain tissue [43] for the positive control.

Signals of the positive controls (PC1 and PC2) corresponding to XMRV - infected macaque plasma and negative control (NC) corresponding to a normal blood donor are highlighted in dark green.

Not exact matches

GOING VIRAL The diversity of viruses carried by such animals as rhesus macaques (one shown) hints at the number of viruses capable of infecting humans that are yet to be discovered.

Macaques do not usually develop genital lesions when infected with HSV2, but in this case, the unvaccinated monkeys showed signs of mild vaginal inflammation soon after exposure to the virus, whereas the vaccinated monkeys showed none.

In the latest study, investigators at NIH's National Institute of Allergy and Infectious Diseases (NIAID) infected six rhesus macaques with MERS - CoV and, eight hours later, treated half of them with the two - drug regimen.

To understand further the neuropathologic effects of Bb infection, researchers infected 12 rhesus macaques with live B. burgdorferi; two animals were left uninfected as controls.

To gain further insight into these concerns, Dr. Michael McCracken of the Walter Reed Army Institute of Research, Maryland, and colleagues infected 25 rhesus macaques with Zika virus.

Rhesus macaques previously infected with dengue or yellow fever viruses appear to be neither more nor less susceptible to severe infection with Zika virus, according to new research published in PLOS Pathogens.

Macaques can't be infected with Plasmodium falciparum, but when the researchers repeated the experiment in mice, using a mouse model of malaria, they found they could reach levels of protection between 71 % and 100 % using intravenous administration.

Given that adipose tissue (which makes up between 15 and 20 % of the body weight in healthy people) is a source of inflammation in obese individuals, Christine Bourgeois and Olivier Lambotte, from the University Paris SUD, France, and colleagues, decided to investigate a possible role of the adipose tissue in humans infected with HIV and in macaques infected with simian immunodeficiency virus (SIV, an HIV relative that causes AIDS - like disease in some non-human primates).

This image shows how the AIDS pathogen (yellow) declines in an infected rhesus macaque after receiving antiretroviral drugs.

While researchers could not identify how a particular animal became infected, treponemal infections are known to be transmitted by contact with the skin lesion of an infected individual, so a pet macaque could potentially pick up the bacteria, said Lisa Jones - Engel, a UW research assistant professor of anthropology who led the study.

To do that, a team including Kash and Katze infected seven macaques with the reconstructed virus.

CMMT (a rhesus macaque mammary tumor line) infected with the amphotropic retroviral vector LT4SN to express human CD4.

In this report, we describe the variations in serum antibody responses and disease manifestations in rhesus macaques infected with B. burgdorferi by tick bite.

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

The research showed evidence that in rhesus macaques infected with simian immunodeficiency virus (SIV), the monkey form of HIV, loss of IL - 17 producing CD4 + and CD8 + T cells was associated with damage to the colon epithelium and with immune activation (see Monkey Matters, IAVI Report, Nov. - Dec.

At a March 25 session at the Keystone Symposia's HIV Vaccines conference, Brenchley presented new data from a study of pigtail macaques chronically infected with the highly pathogenic SIVmac239 strain that suggests probiotics in combination with antiretroviral therapy (ARVs) enhance mucosal immunity and could possibly improve the long - term prognosis of people with HIV.

During the lecture, Picker discussed his work showing that an extensive treatment with CMV, a persistent virus that stays in the body without causing symptoms, can be used to target and clear SIV, a close cousin of HIV that infects rhesus macaques.

Assay positive controls (PCs) were derived from XMRV - infected rhesus macaque plasma at 1 ∶ 1000 (PC1) or 1 ∶ 4000 (PC2).

In the study by Embers» team, published in the journal PLOS ONE in 2012, three rhesus macaques were infected with the Lyme spirochete and treated with a course of oral doxycycline four months later.

Both infected brain and muscle tissues were found to transmit disease to the macaques.