Sentences with phrase «infection model for»

Cross-sectional infection model for skin infections: Histological section through a skin model grown in a test tube, which has been infected with Candida albicans — one of the commonest human fungal pathogens.

«We already established an infection model for the human lung.

Not exact matches

For example, in one activity called «Stem of the Living Dead,» students explore the exponential growth of a zombie hoard and how the spread of the infection creates limited resources using World Health Organization and CDC models and graphs.

Variables were retained in the reduced logistic regression model when their presence was determined to confound the association between human milk feeding and infection or sepsis / meningitis, as defined by a change of > 5 % in the regression coefficient for type of feeding when the variable was removed from the full regression model.

By using this model, they showed for the first time that Pseudomonas aeruginosa colonised the nasopharynx — the part of the body which connects the back of the nose to the back of the mouth — long term and then subsequently migrated down into the lungs to cause chronic infection.

In the study, which included a series of laboratory experiments, field surveys and mathematical modeling, the presence of various species of dragonfly larvae reduced the infections in frogs caused by parasitic flatworms called trematodes, said Val Beasley, professor and head of the department of veterinary and biomedical sciences, Penn State, who worked with Rohr and whose research group collaborated with Lucinda Johnson, senior research associate and director of the Center for Water and the Environment, University of Minnesota Duluth, to complete the field study.

Based on these read - outs, they developed prediction models for the analysis of mosquitoes with unknown infection status.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

The mouse model should also be useful for studying the immunological reactions and viral clearance in hepatitis B virus infection, they note in the Journal of Virology.

The scientists in Rodewald's department, working together with Thomas Höfer, now also plan to use the new model to investigate the impact of pathogenic challenges to blood formation: for example, in cancer, cachexia or infection.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Taking a cue from AIDS researchers, who use simian immunodeficiency virus in monkeys as a model for HIV infection, Fred Wang of Brigham and Women's Hospital and Harvard Medical School in Boston set out to find a primate version of EBV.

Ferrets were used because they are a good model for influenza virus infection.

If we can provide a window for antibiotics to carry out their intended function, we can move towards a clinical model and ultimately cure joint infection,» offered Sana Dastgheyb, Ph.D., lead author on this study and researcher at both Thomas Jefferson University and the National Institutes of Health.

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

Efforts to combat the rapid spread of Zika virus got a boost this week as researchers at the University of Texas Medical Branch, Galveston (UTMB) announced the first peer - reviewed publication of a mouse model for Zika infection reported in decades.

«Given the key similarities to human infections, a marmoset model of Zika may be useful for testing of new drug and vaccines,» said Texas Biomedical Research Institute virologist Jean Patterson, Ph.D. «Having an animal model of Zika infection to study may help us identify places where we might be able to block transmission.»

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

Scientists of Helmholtz Zentrum Muenchen have now established a model for latent HIV infection of brain cells.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

«The protein targets offer a faster, more cost - effective model for rapid screening and diagnoses of viral infections,» Woods said.

Langat virus is found typically in Southeast Asia and is an ideal model virus for study because it causes only rare, mild infections in people.

«Infection model developed for tickborne flaviviruses.»

This type of model could lead to a better understanding of the time - course for the response to an infection or a drug.

Working with the Institute for Disease Modeling in Bellevue, Washington, the researchers tried to predict how much impact a weekly drug could have on preventing HIV infections.

The researchers administered a potential vaccine consisting of two components to twelve rhesus monkeys that served as an animal model for the human HIV infection.

Using infection and mosquito bite data for five villages in Papua New Guinea the team measured biting characteristics to model the impact of bednets on disease control and combined this with geospatial modelling.

Using a mathematical model that combines a huge number of cattle and badgers that have TB, the researchers were able to quantify the relationship between the two animals and use a big data approach to show that the route of infection for cattle is from other cattle rather than from other species.

The rarity of latently infected cells and the lack of a marker for latent HIV - 1 infection necessitate the use of in vitro model systems for detailed studies of this process.

While humanized mouse models for HIV infection have utility, the model is limited due to incomplete immune reconstitution, development of xenogeneic graft versus host disease (GVHD), and the absence of normal T cell homeostasis.

The observed upward trend in associated infections is likely to continue, and aging water distribution systems might soon be an additional reservoir of costly multidrug resistance,» said lead study author Elena Naumova, Ph.D., professor at the Friedman School and Director of the Initiative for the Forecasting and Modeling of Infectious Disease at Tufts University.

Many of the studies developing Drosophila as models for bacterial infections have used bacteria pathogenic to man [5].

Thus several studies have used Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus or Vibrio cholera to look at insects as models for mammalian infection [10]--[15].

«Because the mice used in this model have immune systems that allow them to survive initial infection, they could be particularly helpful for studying the long - term effects of Zika virus infection.»

«We have been working for three years to develop a better research model of brain development, and it's fortunate we can now use this one to shed light on the major public health crisis posed by Zika infections,» says Hongjun Song, Ph.D., professor of neurology and neuroscience at the Johns Hopkins University School of Medicine's Institute for Cell Engineering.

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

For influenza we offer the ferret model, the «gold standard» for infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidatFor influenza we offer the ferret model, the «gold standard» for infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidatfor infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidates.

The researchers, led by UW — Madison pathology Professor David O'Connor, published a study today (June 28, 2016) in the journal Nature Communications describing their work establishing rhesus macaque monkeys at the Wisconsin National Primate Research Center as a model for studying the way Zika virus infections may progress in people.

Exploring cryptosporidiosis with a natural mouse model Adam SaterialeUniversity of Pennsylvania, USA 28 May 201804:15 pm Host: Arturo Zychlinsky, MPIIB, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

Scientists said they now have a testable model for infection in the brain that will spur work in many different areas.

As a proof - of - concept of the atlas's utility as a reference for disease studies, the researchers also surveyed gut epithelial gene expression in two models of intestinal infection, one of Salmonella bacteria, the other of Heligmosomoides polygyrus, a species of helminth (an intestinal parasite).

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections.

7/16/2008 Improved Culture System for Hepatitis C Virus Infection A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible..Infection A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible..infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible... More...

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

Characterization of mitochondrial function in three distinct model systems for Cockayne Syndrome, hCMV - infection and NSC differentiation

Moving forward, the team will be looking for other drugs to test in mouse models of TB infection that can lower levels of miR - 33 to boost the pathways suppressed by TB through this tiny RNA.

Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever.

Whilst we do have some effective animal models for some sexually transmitted infections (e.g. Chlamydia) it is not currently certain if the mouse is an effective model organism for the Zika virus.

Similar to these projects, IDRI's subunit tuberculosis vaccine, ID93, also utilizes adjuvants that induce a cell - mediated immune response, which is required for protection against M. tuberculosis infection in low dose aerosol models of TB.