The variation in the E glycoprotein of Zika virus could explain the ability of the virus to attack nerve cells, as well as the associations of Zika virus
infection with birth defects and the autoimmune - neurological Guillian - Barré syndrome.
Not exact matches
Earlier on Friday, U.S. health officials published a study estimating that as many as 270 babies in Puerto Rico may be born
with the severe
birth defect known as microcephaly caused by Zika
infections in their mothers during pregnancy.
Among them are miscarriage, premature
birth (and therefore being too small to survive outside of a mother's body), problems
with the pregnancy (i.e. preeclampsia, high blood pressure, problems
with the placenta, and
infections),
birth defects (i.e. chromosomal conditions, fragile x syndrome, spina bifida, cystic fibrosis, and others), stillbirth, and SIDS.
Thousands of children in Brazil have been born
with shrunken heads in the past year — a
birth defect that some research suggests could result from Zika
infection.
Zika
infection during pregnancy can also cause serious
birth defects and is associated
with other pregnancy problems.
As of November, there had been 30,000 cases of Zika virus
infection, 3,268 pregnant women
with evidence of Zika
infection and 25 babies born
with Zika - related
birth defects in the U.S. and its territories.
Although the absolute risks for
birth defects were small, physicians should consider prescribing other antibiotics when treating patients
with infections during pregnancy.
An association between Zika
infections during pregnancy and the
birth of babies
with microcephaly (a
birth defect in which an infant's brain does not develop properly resulting in a smaller than normal head) was first suggested by Brazilian physicians in August 2015, and in November microcephaly cases potentially associated
with Zika started to be recorded; three months later WHO made its announcement.
Even as the Zika virus becomes more prevalent — the Centers for Disease Control reports that the number of U.S. infants born
with microcephaly and other
birth defects is 20 times over the normal rate — researchers are still trying to fully pin down the identifying consequences of the viral
infection.
The physical characteristic most associated
with Zika
infection is microcephaly, a
birth defect in which the baby's brain does not develop properly resulting in a smaller than normal head.
In humans, Zika virus
infection during pregnancy has been linked to a suite of
birth defects including a condition known as microcephaly, which leaves babies
with shrunken heads and brains (SN: 4/2/16, p. 26).
Infection with Zika can cause severe
birth defects.
Children
with certain heart
birth defects may have an increased risk for bacterial
infection of their heart's lining and valves, according to new research in Circulation: Journal of the American Heart Association.
The Zika outbreak sweeping across the Americas has coincided
with a surge of devastating
birth defects, but links between these
defects and
infection by the virus have not been firmly established.
The included
birth defects were based primarily on case reports of outcomes occurring in association
with Zika virus
infection during pregnancy; there is more evidence for some of these
birth defects than for others, and a causal link has not been established for all.5,10,12,21 - 27 Because much of the focus to date has been on microcephaly and brain abnormalities, data were summarized in 2 mutually exclusive categories: (1) brain abnormalities
with or without microcephaly regardless of the presence of additional
birth defects and (2) neural tube
defects and other early brain malformations, eye abnormalities, and other consequences of central nervous system dysfunction among those without evident brain abnormalities or microcephaly.
This report describes the US Zika Pregnancy Registry (USZPR) and the proportion of fetuses or infants
with birth defects potentially associated
with maternal Zika virus
infection among women in the USZPR and evaluates whether the proportion
with birth defects differs based on the presence of maternal symptoms of Zika virus
infection or by trimester of possible
infection.
Results Among 442 completed pregnancies in women (median age, 28 years; range, 15 - 50 years)
with laboratory evidence of possible recent Zika virus
infection,
birth defects potentially related to Zika virus were identified in 26 (6 %; 95 % CI, 4 % -8 %) fetuses or infants.
The CDC's guidance recommends Zika virus testing for all women
with possible exposure during pregnancy, regardless of symptoms.16 The findings that there were similar proportions
with birth defects among those
with symptomatic and asymptomatic maternal
infections supports the importance of screening all pregnant women for Zika virus exposure and testing in accordance
with CDC guidance.
Symptoms are typically mild, but according to the Center for Disease Control, there are reports of the
infection leading to «Guillain - Barre syndrome and pregnant women giving
birth to babies
with birth defects and poor pregnancy outcomes.»