Sentences with phrase «infections in human patients»

«But a great deal of work lies ahead to see if this compound has the potential to serve as a less toxic treatment for fungal infections in human patients.

A clinical trial to evaluate whether the ointment can treat antibiotic resistant infections in human patients is scheduled for 2018.

Not exact matches

Nonetheless, if the results translate from mice to humans, they could help inform strategies to prevent secondary infection in patients experiencing sepsis.

But the new test found another seven, including a respiratory virus called human adenovirus B type 3A, which usually is harmless but can cause severe infections in some patients.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)- infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection.

Clinicians treating patients suffering from Middle East respiratory syndrome (MERS) currently have no drugs specifically targeted to the MERS coronavirus (MERS - CoV), a virus first detected in humans in 2012 that has since caused 614 laboratory - confirmed infections, including 181 that were fatal, according to the World Health Organization.

The researchers are now testing this approach in mice, and they envision that eventually the technology could be adapted to deliver the CRISPR components to treat infections or remove other unwanted bacteria in human patients.

«The use of human cellular membranes as a decoy has the potential to block a large family of related microbial toxins and reduce the severity of invasive bacterial infections in vulnerable patients,» said Escajadillo.

Though the findings were made in mice, not humans, the researchers say the crucial role of calcium may help explain another mystery: Why some hospital patients and nursing home residents have a much higher risk of contracting C. diff infections and the resulting diarrhea that carries its spores out of the body.

That finding indicates that very low numbers of the cells in the body could be enough to protect human patients from maladies ranging from infections to cancer.

Tests in mice and nonhuman primates had shown TGN1412 to be safe, but when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T cells that overstimulated the patients» immune systems, resulting in multiple organ failure.

These images provide the first 3D ultrastructural details on HIV infection and virus production in a setting that closely resembles the gut of human patients.

The researchers next showed that the Smurf1 gene controls M. tuberculosis growth in human macrophages and that the Smurf1 protein was found in association with bacteria in the lungs of patients with tuberculosis infections.

Together, these communication and defense capabilities allow P. aeruginosa to form tightly packed layers called biofilms, which can cause respiratory tract infections in humans and are particularly dangerous to cystic fibrosis patients.

OpenBiome was founded to expand safe access to fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the role of the microbiome in human health.

About OpenBiome OpenBiome is the first public stool bank, founded to expand safe access to fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the microbiome's role in human health.

In collaboration with Dr. Josh Thaden and Vance Fowler, Duke University Medical Center, we are exploring relationships between bacterial genetic variation, emergence of AMR, and patient outcome in Enterobacter and Escherichia coli Bloodstream Infections (BSI) by leveraging the Duke University Bloodstream Infection Biorepository (BSIB), which contains robust clinical data, bacterial bloodstream isolates, and corresponding human sera and DNA from over 2000 patients with BSI caused by Gram - negative bacteria at Duke Hospital since 200In collaboration with Dr. Josh Thaden and Vance Fowler, Duke University Medical Center, we are exploring relationships between bacterial genetic variation, emergence of AMR, and patient outcome in Enterobacter and Escherichia coli Bloodstream Infections (BSI) by leveraging the Duke University Bloodstream Infection Biorepository (BSIB), which contains robust clinical data, bacterial bloodstream isolates, and corresponding human sera and DNA from over 2000 patients with BSI caused by Gram - negative bacteria at Duke Hospital since 200in Enterobacter and Escherichia coli Bloodstream Infections (BSI) by leveraging the Duke University Bloodstream Infection Biorepository (BSIB), which contains robust clinical data, bacterial bloodstream isolates, and corresponding human sera and DNA from over 2000 patients with BSI caused by Gram - negative bacteria at Duke Hospital since 2002.

A Phase I evaluation of the safety and immunogenicity of vaccination with recombinant gp160 in patients with early human immunodeficiency virus infection.

The infection tests were done in human cells, including cells derived from SMA patients.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

Two differences in the comparison of experimental monkeys with human patients include the use of multiple ticks for infection and a lab - propagated strain of B. burgdorferi.

He and his colleagues were the first to demonstrate that human antigen - specific T cell clones could be isolated and expanded in vitro and then re-infused into patients to prevent or treat viral infections and to mediate therapeutic responses in patients with cancer.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

Infections with human pathogenic fungi have been continuously increasing during the last years and these fungal pathogens have become a major threat for individuals, in particular for patients with a compromised immune system.

Median = 5 years, [E] ight were hospitalized... The outbreak strain was isolated from a pet turtle in a patient's home... This outbreak demonstrates that turtles remain a source for human Salmonella infections, especially for young children.

Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream infections with Bartonella spp. in healthy and sick animals, and in immunocompetent and immunocompromised human patients with cardiovascular, neurologic, and rheumatologic symptoms.

AHP ® is unique in its ability to help keep humans and animals free from infection, while being safer for users, patients and assets.

Dworkin, M.S., et al Bordetella bronchiseptica Infection in Human Immunodeficiency Virus — Infected Patients Clinical Infectious Diseases, 1999

Petrie, K.J., Pennebaker, J.W. et al. (2004) Effect of Written Emotional Expression on Immune Function in Patients With Human Immunodeficiency Virus Infection: A Randomized Trial.

It also addresses social isolation, a factor that has been linked to increased mortality and morbidity in some studies of patients with CAD.25 Furthermore, IPT was found to be superior to CBT in treating depression in patients with human immunodeficiency virus infection, 26 a group also dealing with comorbid physical and emotional problems.