Sentences with phrase «infectivity in»

Infectivity in Chimpanzees (Pan troglodytes) of Plasma Collected before HCV RNA Detectability by FDA - Licensed Assays: Implications for Transfusion Safety and HCV Infection Outcomes.

Lentiviral particles with the VSV - G envelope have high infectivity in a wide range of cell types, so they're ideal for work with primary cells or other difficult - to - transfect cells.

Investigators also have a variety of specialized resources for testing virus infectivity in various bugs and animals, sequencing viral genes and imaging pathogen structures.

Thus, as postulated by the prion hypothesis, the infectivity in mammalian prion disease results from an altered conformation of PrP.

Not exact matches

The low dose required for infectivity and the severity of the disease it causes had led the Centers for Disease Control and Prevention to classify F. tularensis as a Category A bioterrorism agent, and to track tularemia cases nationwide, according to Dr. Brook Peterson, a senior scientist at the UW School of Medicine who also participated in the study.

Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity.

In collaboration with many researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of influenza; the impact of behavioral changes, long periods of infectiousness, variable infectivity, co-infections, prostitution, social networks, and vaccine efficacy on HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales for epidemics of foot and mouth disease.

Since then, prisons have changed and the notorious policy of Viral Infectivity Restrictions (VIR), which was singled out for particularly fierce criticism in the report, has been abandoned.

Two studies published by Cell Press June 6th in the journal Cell identify mutations that increase the infectivity of H5N1 and H7N9 viruses through improved binding to receptors in the human respiratory tract.

We have successfully evolved families of aptamers targeting the HIV envelope that neutralize HIV infectivity, yet can be internalized in HIV infected cells to deliver therapeutic siRNAs.

«It all suggests that there may be a cluster of Hendra virus strains, all closely related, but differing in their pathogenesis and infectivity,» he says.

These models include in vitro experiments with purified recombinant or synthetic proteins, cell culture experiments, and infectivity studies with Tg mice expressing the appropriate form of the protein.

Because we lack serology data on people in regions of Ebola outbreaks, it is not known whether there are infected individuals who remain asymptomatic; therefore, the degree of infectivity of the virus is unknown.

Because people exposed to Ebola show phenotypic variability in susceptibility to infection and disease severity, it is likely that human genetic variation contributes to individual immunity and infectivity and that host genetic differences are one factor among many that interact to influence the infection.

Env clones with inserts in the correct orientation screened for infectivity by co-transfection with an env deficient HIV - 1 (SG3env) backbone in 293T cells

Env clones with inserts in the correct orientation screened for infectivity by cotransfection with an env deficient HIV - 1 (SG3env) backbone in 293T cells

We further hypothesized that the fitness of persistent B. burgdorferi obtained from treated and untreated animals would be evident as differences in infectivity when injected into mice.

While the molecular results seemed to indicate dissemination of B. burgdorferi obtained from XT in SCID mice, we are hesitant to consider this evidence of infectivity, owing to the inconsistency of results.

Nonhuman and human primates are generally considered «dead end» hosts, so adaptation in this host may engender a phenotype of reduced infectivity for subsequent hosts; this is likely an uncontrollable characteristic of the model system, rather than an indication of the viability of the spirochetes.

In the case of Influenza A, the loss of RNA exosome activity severely compromises viral infectivity, but also manifests in human neurodegeneration suggesting that viruses target essential proteins implicated in rare disease in order to ensure continual adaptatioIn the case of Influenza A, the loss of RNA exosome activity severely compromises viral infectivity, but also manifests in human neurodegeneration suggesting that viruses target essential proteins implicated in rare disease in order to ensure continual adaptatioin human neurodegeneration suggesting that viruses target essential proteins implicated in rare disease in order to ensure continual adaptatioin rare disease in order to ensure continual adaptatioin order to ensure continual adaptation.

To demonstrate that the defective phenotype of ospC7 was due to the lack of OspC and to determine whether reintroduction of ospC was sufficient to restore mouse infectivity, we complemented the ospC mutation in ospC7 by integrating a WT copy of ospC adjacent to the mutated ospC gene on cp26 (Fig. 1).

BB0844, an RpoS - Regulated Protein, Is Dispensable for Borrelia burgdorferi Infectivity and Maintenance in the Mouse - Tick Infectious Cycle

The newly identified site can be attacked by human antibodies in a way that neutralizes the infectivity of a wide variety of HIV strains.

The scientists determined that the two broadest neutralizers among these antibodies, PGT151 and PGT152, could block the infectivity of about two - thirds of a large panel of HIV strains found in patients worldwide.

The serum from a small set of the samples indeed turned out to block the infectivity, in test cells, of a wide range of HIV isolates, suggesting the presence of broadly neutralizing antibodies.

Associating proportional changes in the viral titre of nasal washes in the ferret study [16] with proportional changes in viral titres in nasal sprays in the human challenge studies [39], and taking the household SAR to approximate natural infectivity, we estimated the antipyretic - induced individual transmission enhancement factor fi using equation S22 in the electronic supplementary material.

The limited infectivity of persisting non-cultivable B. burgdorferi has no biological significance for the natural enzootic cycle of B. burgdorferi, but it remains to be determined if they have significance in the post-treatment host.

Across populations, kiwi is used in the preparation of antimicrobial products to reduce the development of resistance towards the conventional medications for fungal and bacterial infectivity.

As for the alleged predisposition of a given ethnicity to an exacting ailment, augmented vulnerability to infectivity, etc., such qualities, in general, don't demonstrate an «ethnic» nature, but are associated with societal, enlightening and extra living conditions, the closeness of hot spots of contamination, the grade of adaptation during immigration, and all that.

Multiple serovar vaccines also lead to difficulty in determining which serovar is the serovar of infectivity.