The limited
infectivity of persisting non-cultivable B. burgdorferi has no biological significance for the natural enzootic cycle of B. burgdorferi, but it remains to be determined if they have significance in the post-treatment host.
Inactivation of bb0184, Which Encodes Carbon Storage Regulator A, Represses
the Infectivity of Borrelia burgdorferi
The scientists determined that the two broadest neutralizers among these antibodies, PGT151 and PGT152, could block
the infectivity of about two - thirds of a large panel of HIV strains found in patients worldwide.
The newly identified site can be attacked by human antibodies in a way that neutralizes
the infectivity of a wide variety of HIV strains.
Infectivity of the Highly Transformable BBE02 - lp56 - Mutant of Borrelia burgdorferi, the Lyme Disease Spirochete, via Ticks
Effects of vlsE Complementation on
the Infectivity of Borrelia burgdorferi Lacking the Linear Plasmid lp28 - 1
SAN FRANCISCO, CA — Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have discovered a new agent that might inhibit
the infectivity of HIV.
When treated with chloroform,
the infectivity of the BYDV droped from 105.8.
Because we lack serology data on people in regions of Ebola outbreaks, it is not known whether there are infected individuals who remain asymptomatic; therefore, the degree of
infectivity of the virus is unknown.
Two studies published by Cell Press June 6th in the journal Cell identify mutations that increase
the infectivity of H5N1 and H7N9 viruses through improved binding to receptors in the human respiratory tract.
Cholesterol is known to affect the virulence and
infectivity of TB.
«Understanding the notorious
infectivity of Francisella tularensis: Fresh approach to an old problem yields clues to tularemia virulence.»
Scientists are gaining an insider's look behind the notorious
infectivity of Francisella tularensis.
The idea is that scrapie prions might somehow interfere with
the infectivity of BSE prions.
The lower
infectivity of HIV - 2 compared to HIV - 1 implies that fewer of those exposed to HIV - 2 will be infected per exposure.»
Not exact matches
Our synthetic loops showed almost exactly the same patterns
of infectivity as their natural counterparts had.
The low dose required for
infectivity and the severity
of the disease it causes had led the Centers for Disease Control and Prevention to classify F. tularensis as a Category A bioterrorism agent, and to track tularemia cases nationwide, according to Dr. Brook Peterson, a senior scientist at the UW School
of Medicine who also participated in the study.
Exposure
of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration
of infectivity.
In collaboration with many researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role
of cross-immunity on the evolution and dynamics
of influenza; the impact
of behavioral changes, long periods
of infectiousness, variable
infectivity, co-infections, prostitution, social networks, and vaccine efficacy on HIV dynamics; the role
of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact
of life - history vector dynamics on dengue epidemics; and on the identification
of time - response scales for epidemics
of foot and mouth disease.
For example, their surface is covered by glycoconjugates that are essential for their survival and
infectivity, but little is known
of the processes that lead to the synthesis
of such molecules.
Thus, as postulated by the prion hypothesis, the
infectivity in mammalian prion disease results from an altered conformation
of PrP.
Since then, prisons have changed and the notorious policy
of Viral
Infectivity Restrictions (VIR), which was singled out for particularly fierce criticism in the report, has been abandoned.
ON 14 December 1967, Arthur Kornberg at Stanford University and colleagues announced that they had copied the DNA
of the Phi X174 virus, producing an entity with the same
infectivity as the wild virus.
They find statistical support for high viral
infectivity rates
of dengue serotypes 2 and 3 relative to dengue 1.
«There is not one iota
of evidence whatsoever that
infectivity can occur from one individual to another,» says cell biologist and neuroscientist
Investigators also have a variety
of specialized resources for testing virus
infectivity in various bugs and animals, sequencing viral genes and imaging pathogen structures.
Researchers also found that plants can uptake prions from contaminated soil and transport them to different parts
of the plant, which can act as a carrier
of infectivity.
We have successfully evolved families
of aptamers targeting the HIV envelope that neutralize HIV
infectivity, yet can be internalized in HIV infected cells to deliver therapeutic siRNAs.
«It all suggests that there may be a cluster
of Hendra virus strains, all closely related, but differing in their pathogenesis and
infectivity,» he says.
It is thought that the ability
of misfolded prion protein to serve as a nucleus for the misfolding and aggregation
of the host prion protein is the key property responsible for prion replication and
infectivity (Soto et al., 2006; Soto, 2012).
These models include in vitro experiments with purified recombinant or synthetic proteins, cell culture experiments, and
infectivity studies with Tg mice expressing the appropriate form
of the protein.
Genetic markers
of infectivity or likelihood
of being a super-spreader could be used to justify quarantine and isolation policies, with the concomitant implications for individual liberty.
Strategies for the clinical management and public health control
of different infectious diseases vary depending on the acuteness and chronicity
of infection,
infectivity and virulence
of the causative pathogen, modes and ease
of transmission, and whether there are effective treatments, vaccines, or other means
of prevention.
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration
of infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbicides
«Our study shows for the first time exactly how immune cells sense the virus and how the virus uses one
of its proteins to tune its stealthiness and
infectivity,» says senior study author Nicolas Manel
of the Institut Curie.
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: B This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbicides Enterpri
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e4.9 Full - length genome: SUBTYPE F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccin
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e5.4 SUBTYPE: BF1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbicides Enterpr
Syncytium inducing phenotype (MT2): NSI Coreceptor use: CCR5 Titration
of infectivity (TCID50 / ml): 10e4.6 Full - length genome: C This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbi
Identification and characterization
of PWWP domain residues critical for LEDGF / p75 chromatin binding and human immunodeficiency virus type 1
infectivity.
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e6.2 SUBTYPE: F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbicides Ent
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e4.2 Full - length genome: SUBTYPE F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccine
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e6.4 Full - length genome: SUBTYPE B This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines a
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e6.8 SUBTYPE: BG (URF) This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbici
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e6.8 SUBTYPE: BF (URF) This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbici
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration
of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence European Vaccines and Microbicides Enterpr
Syncytium inducing phenotype (MT2): NSI Coreceptor use: CCR5, CXCR4: R5 Titration
of infectivity (TCID50 / ml): 10e5.6 Full - length genome: SUBTYPE F1 This isolate is part
of an European Panel
of HIV - 1 isolates form the Network
of Excellence Euro
Lentiviral particles with the VSV - G envelope have high
infectivity in a wide range
of cell types, so they're ideal for work with primary cells or other difficult - to - transfect cells.
Overall risk Tularaemia is considered to be dangerous because
of its extreme
infectivity and because it is easily spread.
We further hypothesized that the fitness
of persistent B. burgdorferi obtained from treated and untreated animals would be evident as differences in
infectivity when injected into mice.