The incredible ability of curcumin to promote various pathways like gene transcription factors,
inflammatory cytokine pathways and various growth factors means that it has been studied for the many potential benefits for skin conditions like psoriasis, skin cancers, dermatitis, acne, wound healing and even keloid scars.
As an Associate Professor at OSU, my research has been concentrated in the areas of aging, neuroimmunology, and neurotrauma.Overall, my research aim is to determine the degree to which the bi-directional communication between the brain and the immune system is affected by age, stress, and traumatic CNS injury and to delineate the mechanism by which
inflammatory cytokine pathways cause long - lasting complications (e.g., cognitive decline and depression).
Putative Transcriptomic Biomarkers in
the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients.
Not exact matches
The stressor also activates key
inflammatory pathways in peripheral blood cells and increases in levels of pro-
inflammatory cytokines.
Huntington's monkeys also show levels of
inflammatory markers (
cytokines and
inflammatory pathway genes) in their blood that is greater than in controls.
They showed that rapamycin reduced the secretion of
inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR
pathway, which promotes growth.
Inflammatory Cytokine TSLP Stimulates Platelet Secretion and Potentiates Platelet Aggregation via a TSLPR - Dependent PI3K / Akt Signaling
Pathway.
[23, 43, 44, 55] Among the affected
pathways is the PI3K - AKT, which regulates
inflammatory cytokines through NF - κβ.
[43, 44, 56] Activation of the NF - κβ
pathway by
inflammatory cytokines has also been shown to enhance drug resistance in breast cancer.
Chronic inflammation happens when something in the
inflammatory pathways goes awry — essentially the body does not stop producing certain
inflammatory cytokines and the
inflammatory response does not shut off, leaving the body in a state of chronic pain.
And so that consumes a lot of resources; it creates a lot of
inflammatory cytokines; it also regulates some other
pathways, which can be circulated, end up in the brain and end up causing anxiety and depression.
Intracellular levels of NAD + regulate immune and
inflammatory pathways, including the
cytokine TNF - alpha, a critical signaling molecule.34, 35
As anticipated, since we are working with blood samples, the
inflammatory and immune response categories with specific signaling
pathway such as
cytokines signaling between immune cells, IL - 6 and IL - 10 signaling were identified in our analysis.
Consistent with other investigators, 22,58 there were not reliable relationships between the local production of
cytokines at
inflammatory sites and levels in systemic circulation (data not shown); thus, local production is the primary presumptive
pathway.22, 58