Sentences with phrase «inflammatory diseases of old age»
«It is well established that there is a «hyper - inflammatory phenotype» based largely on genetic factors that is of value in protecting the young from bacterial infection before they have made IgG antibodies to the bacteria they encounter; but which, in later life predisposes to the inflammatory diseases of old age.
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Lastly, increased systemic inflammation seen during ageing is also apparent in chronic infections such HIV or cytomegalovirus, 10,15 obesity7 and individuals enduring chronic psychological stress.16 Similarly, the main features of immunosenescence are apparent in many of these conditions, including decreased antibody responses, increased infections, malignancies and also incidences of inflammatory associated disorders such as cardiovascular disease.7, 10,15,16 Inflammation and premature immunosenescence are, therefore, prevalent features of many common conditions of modern life, such as obesity and stress, and could have negative health consequences for large proportions of society well before old age is reached.