Sentences with phrase «inflammatory pathways as»

Gladstone scientists identify inflammatory pathways as a potential therapeutic target for frontotemporal dementia

Not exact matches

To the Penn scientists, the findings indicate that blocking the CCL2 - CCR2 inflammatory pathway in pancreatic cancer is worth investigating as an add - on to radiation therapy, not just to chemotherapy.

They found that the compound reduces levels of a key protein — known as IkappaBzeta — in the IL - 17 inflammatory pathway.

On the flip side, turning up expression of these genes or their pathways could help researchers grow new intestinal tissue to replace tissue destroyed by diseases such as inflammatory bowel disease or radiation treatment for cancer.

The compound suppresses an inflammatory pathway that is overactive in many autoimmune diseases, suggesting that it may be effective against multiple sclerosis, rheumatoid arthritis, lupus and other autoimmune diseases as well as psoriasis.

Strikingly, diseases such as rheumatoid arthritis all feature inflammatory processes driven by JAK / STAT activity and the effectiveness of MTX in these inflammatory diseases may well be a consequence of its ability to dampen the JAK / STAT pathway.

As an Associate Professor at OSU, my research has been concentrated in the areas of aging, neuroimmunology, and neurotrauma.Overall, my research aim is to determine the degree to which the bi-directional communication between the brain and the immune system is affected by age, stress, and traumatic CNS injury and to delineate the mechanism by which inflammatory cytokine pathways cause long - lasting complications (e.g., cognitive decline and depression).

Development of inhibitors of metabolic pathways to block oncogenes or signalling molecules in malignant processes and specific inflammatory processes, such as pulmonary artery hypertension or idiopathic pulmonary fibrosis.

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen - sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies.

Peroxisome proliferator - activated receptors (PPAR) are a family of transcription factors induced by various ligands that act as anti-inflammatory agents by interfering with inflammatory signaling cascades, including the NFκB pathway.

Removing the inflammatory foods will then help your body to heal as the reactants will no longer be able to activate immune pathways.

In today's high - stress, high - inflammatory world, I see this frequently and it's usually as a result of a suppressed HPG (hypothalamus, pituitary, gonadal) communication pathway.

As anticipated, since we are working with blood samples, the inflammatory and immune response categories with specific signaling pathway such as cytokines signaling between immune cells, IL - 6 and IL - 10 signaling were identified in our analysiAs anticipated, since we are working with blood samples, the inflammatory and immune response categories with specific signaling pathway such as cytokines signaling between immune cells, IL - 6 and IL - 10 signaling were identified in our analysias cytokines signaling between immune cells, IL - 6 and IL - 10 signaling were identified in our analysis.