In the study, the researchers detected a very small number of SIV infected cells in the gut within initial 2.5 days of viral infection; however,
the inflammatory response to the virus was playing havoc with the gut lining.
Not exact matches
Wilson engineered AdV
to provoke less of an
inflammatory response in the body, ultimately creating what he thought was the right version of the
virus.
While the
inflammatory immune
response is essential
to protecting humans against
viruses and bacteria, superantigen toxins cause an exaggerated
response called an «immune storm» that can do a great deal of damage in the body and can result in multiple organ failure.
When injected into animals, Bachmann's
virus - bacteria hybrid induces a strong antibody
response that his company, Cytos Biotechnology, is exploiting
to design vaccines against two common
inflammatory disorders.
«We compared the ability of RSV and parainfluenza
virus (PIV3)-- another common
virus in children that causes much less severe airway disease —
to infect and cause
inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.
Researchers compared the
inflammatory response of control - treated versus simvastatin - treated cells
to RV by measuring CXCL10 secretion, an implicated therapeutic target for
virus - induced asthma exacerbations.
Instead of responding
to viruses or other foreign invaders in the body, the activated CD8 + T cells launch an
inflammatory response to fat, and
to bacterial components that migrate
to the liver from the gut through the blood.
2009 Pandemic H1N1 Influenza
Virus Causes Disease and Upregulation of Genes Related
to Inflammatory and Immune
Responses, Cell Death, and Lipid Metabolism in Pigs.
«When we saw how much inhibiting PLSCR1 reduced the
inflammatory response, we immediately wondered if this mechanism could apply more broadly, not just
to virus infection of the brain, but
to other types of infections or even autoimmune diseases,» says Yusuf Tufail, a former Salk postdoctoral fellow and first author of the paper.
However,
viruses, while effective, introduce other problems
to the body, such as toxicity, immune and
inflammatory responses, and gene control and targeting issues.
Shortened sleep also seems
to alter the
inflammatory response, which helps our bodies clear out
viruses when it's functioning properly, he says.
Stressed people's immune cells become less sensitive
to cortisol and so they are unable
to regulate the
inflammatory response, and therefore, when they're exposed
to a
virus, they're more likely
to develop a cold.
On the other hand, some birds will be tested for PDD with the PCR at a point when they are no longer shedding the
virus, but later go on
to develop the disease owing
to the
inflammatory immune
response.