If mechanical stresses can
influence cell fate — and Levenston's research is showing that it can — then one day it may be possible to use these biomechanical manipulations to engineer cartilage, ligament, or muscle.
The study sought to test whether the surface alone, absent any added soluble factors to
influence cell fate decisions, can have an effect on differentiation.
miRNAs function as important regulatory switches,
influencing cell fate decisions and tumor development.
Not exact matches
Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the
cell differentiation equation, showing that the stiffness of the surfaces on which stem
cells are grown can exert a profound
influence on
cell fate.
The presence of certain proteins can
influence the
cell's
fate.
Each ended up taking on the characteristics of its new neighbors, implying that the environment that they grew up in strongly
influenced the
fate of these
cells.
The relative simplicity of the process means biologists have a much greater chance of reliably
influencing stem
cell fate.
iPS - generated neurons, he says, may be of little use in replicating the
fate of motor
cells buffeted by a lifetime of drug exposure and other metabolic and environmental
influences.
In some cases, the jump altered gene expression in a way that
influenced the stem
cells»
fate — making them more likely to turn into neurons, for example.
They study the mechanism of genome organization in development, homeostasis — metabolic balance — and aging; and the
influence of
cell morphogenesis, or
cell shape and steructure, on
cell fate decisions.