To illustrate potential mutation - specific effects
on absolute cancer risks, we used the hazard ratio estimates to derive approximate absolute risks and 95 % confidence intervals, based
on published estimates for the overall risks of breast and ovarian cancer by age 70 years.26 These estimates are for illustration and do not represent absolute risk estimates that would be required in a genetic counseling setting, as they do not account for noncancer outcomes that may
influence a woman's
life expectancy, the effects of family history, and nonrandom ascertainment of mutation carriers in this sample and depend
on assumptions about the prevalence of different mutation classes in the population.
And we reasoned that studying veterinary teaching hospital - based populations of dogs with artifactually low
life expectancies (for example, 3.5 years is median age at death for Rottweilers in the Veterinary Medical Data Base)(5) was an inappropriate vehicle to describe the
influence that ovaries have
on aging.