Researchers using data collected by the Ovarian Cancer Association Consortium have discovered uncommon variants in new regions of the genome that
influence ovarian cancer risk, and will present their findings on April 6, 2014 at the American Association for Cancer Research Annual Meeting in San Diego, CA.
To illustrate potential mutation - specific effects on absolute
cancer risks, we used the hazard ratio estimates to derive approximate absolute
risks and 95 % confidence intervals, based on published estimates for the overall
risks of breast and
ovarian cancer by age 70 years.26 These estimates are for illustration and do not represent absolute
risk estimates that would be required in a genetic counseling setting, as they do not account for noncancer outcomes that may
influence a woman's life expectancy, the effects of family history, and nonrandom ascertainment of mutation carriers in this sample and depend on assumptions about the prevalence of different mutation classes in the population.