Sentences with phrase «influences gene expression»

In addition, he has also discovered another protein that can be affected by drugs and directly influences gene expression in both cancer and heart failure.

The method uses computational algorithms to learn how genome sequence influences gene expression, based on large - scale transcriptome datasets such as GTEx.

Undoubtedly there is sequence variation that influences gene expression but isn't well - captured by SNP arrays.

Hormone ‐ replacement therapy influences gene expression profiles and is associated with breast ‐ cancer prognosis: a cohort study

Variability in the tail — in length or in their position, affects the function of the messenger molecules, and hence influences gene expression.

Previous work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different cell types are organized differently in three dimensions.

They also identify where chemical modifications of DNA influence gene expression and where various functional forms of RNA, a form of nucleic acid related to DNA, help regulate the whole system.

As for the HARs that weren't active in brain cells during the study, the scientists think they could influence gene expression at other time points during development, such as when the neuron is fully matured rather than while it's developing.

When people eat a plant - heavy diet, the fiber from the plant matter ferments in the gut and creates short - chain fatty acids, which, in turn, regulate the immune system and influence gene expression in the brain and elsewhere.

We now know that changes in methylation state also have key roles in influencing gene expression,» Mullighan said.

Hormones are messengers that attach directly to the DNA of trillions of our cells and influence gene expression.

Sleep, nutrition, relationships, stress, movement... those all matter, because they are modifiable elements of our lifestyle that influence gene expression.

Now not only can we order a test in the public domain which charts out DNA and the specific genes we carry, but we can learn how you can significantly influence gene expression called epigenetics, and thus improve your health with a personalized nutrition program and lifestyle choices.

Hormones are messengers that attach directly on to the DNA of trillions of our cells and influence gene expression.

Poor nutrition: Those methyl groups we discussed that influence gene expression are actually made directly from the nutrients you eat, such as folate from green vegetables.

Not exact matches

Then they shifted to genetic determinism — gene expression exacerbates or mitigates environmental influence.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

Delving into imprinting is also yielding insights into the scaffolding of the genome, and the ways in which parents put a stamp on gene expression, influencing health and disease in their children.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features — chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

This magic spot was later identified as ppGpp and shown to influence the expression of over 500 genes in response to stress.

In addition, specific genes that influenced photosynthesis and other important plant responses differed in expression.

Booij and her colleagues hope that this study will shed more light on the specific role of early environmental influences on brain development, gene expression and emotional regulation.

«Gut's microbial community shown to influence host gene expression.»

And in 2012, they uncovered the first evidence that sleep apnea influences epigenetics, altering gene expression without changing an individual's DNA.

«This is by far the largest twin study of gene expression ever published, enabling us to make a roadmap of genes versus environment,» Sullivan says, adding that the study measured relationships with disease more precisely than had been previously possible, and uncovered important connections to recent human evolution and genetic influence in disease.

Through colorful anecdotes and commonsense explanations, author Richard C. Francis, who holds a Ph.D. in biology, delivers an engaging tour of the new science of epigenetics, the study of environmental influences on gene expression.

For instance, a tumor influences the expression of genes in immune system cells that are involved in the body's response to cancer.

Research has shown that a cell's physical surroundings can influence its shape, physiology, and even the expression of its genes.

For example, because one's genes generally aren't subject to change, any change in the influence or expression of one's genes is likely «triggered» by other biological and / or environmental processes.

That would be a way to influence the expression of many genes involved in the proliferation of cancer cells.»

«The authors have done a very elegant job showing a clear connection among environmental influence, gene expression, and behavior,» says Mark Winston, an entomologist at Simon Fraser University in Vancouver, Canada.

Mal - gluc modulates histone acetylation of the Rac1 gene and allows transcription activators to access the DNA for increased transcription in the brain, which influences the expression of genes responsible for synaptic plasticity.

In some cases, the jump altered gene expression in a way that influenced the stem cells» fate — making them more likely to turn into neurons, for example.

«It is also possible that these data will reveal that some previously identified disease - associated sequence variants actually fall within a formerly unrecognized primary miRNA gene, thereby raising the possibility that such variants may influence expression of the encoded miRNA,» Mendell said.

«It is important to understand how nucleosomes are moved, ejected or restructured, as this will affect the accessibility of promoter DNA, which in turn influences the expression of the corresponding genes,» explains David Shore, professor at the Department of Molecular Biology of the Faculty of Science at UNIGE.

Mendel's regulatory gene controls the expression of other genes that influence cold resistance, and its use represents the state of the art in plant biotech.

Genome - wide analysis of variance (ANOVA) revealed that germline SNPs / CNVs and somatic CNAs influenced > 39 % of gene expression probes, roughly half acting in cis and half in trans.

Otherwise, it does seem to suggest that germline SNPs have a greater influence than CNVs when it comes to modulating gene expression.

It's possible that inherited regions of CNV with strong influence on gene expression are targeted for amplification / deletion by cancer cells, which might obscure their effect in an otherwise normal cell.

We show, for the first time, the influence of the gene expression levels demonstrating the power of «big data» to change how medical research is performed.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

In terms of the potential impact of the risk - associated variants, about half the risk for both disorders appears to be accounted for by variants already known to influence the expression of genes in the brain.

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs.

Expression and functional analyses of the gene strongly suggest that PDE4D plays an important role in atherosclerosis, most likely by influencing the proliferation and migration of smooth muscle cells within arteries that is central to the biology of ischemic stroke.

Additionally, sex differences were recently also described in the transcriptome of human placental cells, demonstrating an influence of fetal sex on placental gene expression in a cell - type dependent manner (186).

Starvation influences the microbiota assembly and expression of immunity - related genes in the intestine of grass carp (Ctenopharyngodon idellus)-- Ngoc Tuan Tran — Aquaculture

Lobo, Ingrid, Ph.D. «Environmental Influences on Gene Expression.»