Sentences with phrase «influenza infection during pregnancy»

Findings In a cohort study of 196 929 children, of whom 3103 had austism spectrum disorder, maternal influenza infection during pregnancy was not associated with increased autism risk.

Maternal influenza infection during pregnancy was not associated with increased ASD risk in this study, and the association did not vary by the timing of influenza infection.

In a cohort study of 196 929 children, of whom 3103 had austism spectrum disorder, maternal influenza infection during pregnancy was not associated with increased autism risk.

These results are similar to our previous findings and 2 recent studies of no association between influenza infection during pregnancy and ASD risk.8, 10,11,13 Our previous 2 studies were limited by small sample sizes and possible recall bias, which were addressed in this study by using a larger sample size and electronic medical records.

Influenza viruses are prevalent worldwide, and it is estimated that more than 200 000 people in the United States are hospitalized each year for respiratory and heart conditions, illnesses associated with seasonal influenza virus infections.14 Previous epidemiological studies on associations between influenza infection during pregnancy and ASD reported mixed results.

We found no association between ASD risk and influenza infection during pregnancy or influenza vaccination during the second to third trimester of pregnancy.

Not exact matches

«This suggests that during pregnancy, a typical influenza infection could hit very hard.»

After controlling for maternal and child covariates, we found that maternal influenza infection anytime during pregnancy was not associated with increased ASD risk (adjusted HR [AHR], 1.04 [95 % CI, 0.68 - 1.58]-RRB-.

Each study participant's mother was identified from KPNC electronic medical records and data on maternal exposures during pregnancy (eg, influenza infection and influenza vaccination), and covariates were extracted.

After adjusting for covariates, we found that maternal influenza infection (adjusted hazard ratio, 1.04; 95 % CI, 0.68 - 1.58) or influenza vaccination (adjusted hazard ratio, 1.10; 95 % CI, 1.00 - 1.21) anytime during pregnancy was not associated with increased ASD risk.

Conclusions and Relevance There was no association between maternal influenza infection anytime during pregnancy and increased ASD risk.

A small proportion of women were exposed to both influenza infection and influenza vaccination during pregnancy (0.2 %).

Data on influenza infection and vaccination during pregnancy were obtained from KPNC inpatient and outpatient databases.

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder.