Immunohistochemical staining of the tissues was carried out for
the influenza nucleoprotein detection in sparrows» tissues.
Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1
influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.
Not exact matches
The study also suggests ways to make
influenza vaccines even safer, for instance by keeping the
nucleoprotein levels low or removing the specific region of the protein that mimics the receptor.
The mouse is described in a study, «In vivo evasion of MxA by avian
influenza viruses requires human signature in the viral
nucleoprotein,» that will be published April 10 in The Journal of Experimental Medicine.
MxA is thought to target
influenza A by binding to the
nucleoprotein that encapsulates the virus» genome, and mutations in this
nucleoprotein have been linked to the virus» ability to infect human cells.
MxA is therefore a barrier against cross-species
influenza A infection, but one that the virus can evade through a few mutations in its
nucleoprotein.
Her first major discovery, in 2006, identified a loop in the
nucleoprotein of the H1N1 human
influenza virus.