Emory
influenza researchers Richard Compans, Anice Lowen and John Steel are co-signers of a statement announcing the end of a self - imposed moratorium on H5N1 avian flu research.
Almost a year after they announced it, leading
influenza researchers are ending a voluntary moratorium on certain types of controversial experiments involving the H5N1 avian influenza virus.
But the agency says the data will be useful to
influenza researchers anyway.
Human
influenza researchers, who mainly work with ferrets and mice as models, have turned up provocative findings about the new virus in a remarkably short time.
The group, which included leading
influenza researchers and public health officials, has no authoritative power.
An international team of
influenza researchers in China, the United Kingdom and the United States has used genetic sequencing to trace the source and evolution of the avian H7N9 influenza virus that emerged in humans in China earlier this year.
Ilaria Capua, a former avian
influenza researcher and now a member of the Chamber of Deputies, agrees that Italy should respect its obligations within the European Union and pass a law that is compliant with the directive.
«We thought it would be useful for people to know what changes they should be looking for,» says Nancy Cox,
an influenza researcher at the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta, who helped assemble the inventory with researchers from around the world.
Not exact matches
Researchers in my lab think that this impact of
influenza infection on muscles is another unintended consequence of the immune response to the virus.
There was no association between pregnant mothers who received the
influenza or tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccines and the risk of infant death or hospitalization,
researchers found.
The
researchers assessed three primary outcomes: the incidence of laboratory confirmed infant
influenza from 0 - 180 days post birth; the incidence of low birth weight; and the incidence of
influenza - like illness in mothers 0 - 180 days following delivery.
But with such a massive industry across the U.S., scientists are only just starting to get a handle on this continual mingling of various stocks of hogs and viruses, Martha Nelson, a
researcher at the Fogarty International Center at the National Institutes of Health, explained earlier this month at the fourth European Working Group on
Influenza conference in Malta.
As carriers — and fertile mixing grounds — for
influenza A strains that could cause illness or even pandemic in humans, hogs are important subjects for flu
researchers.
For the past three decades,
researchers and health workers have engaged in a similar battle against one of the most cunning viruses to afflict humanity and much of the animal world: the dread
influenza virus.
Nelson and her colleagues found that flu in pigs «follows long - distance swine movements from the southern U.S. to the Midwest,» with most of the human - origin H1N1 arriving at Midwest hog farms coming from the Southeast, and most of the swine - origin H1N2 coming from the south - central U.S. And that means the Midwest, as the final destination for many of these pigs, is «likely to provide a reservoir for multiple genetically distinct variants to co-circulate and exchange segments via re-assortment because of the continual importation of swine
influenza viruses from other regions,» the
researchers noted.
In the new study,
researchers at the NIAID used a virus - like particle vaccine cocktail that expressed a handful of different subtypes of a key surface protein of the
influenza virus: hemagglutinin H1, H3, H5 and H7.
Each year, scientists create an
influenza (flu) vaccine that protects against a few specific
influenza strains that
researchers predict are going to be the most common during that year.
What
researchers do know is that
influenza is an RNA virus, which mutates easily and rapidly.
In a series of experiments, the
researchers found that 95 % of mice vaccinated with the investigational cocktail were protected against a lethal challenge with eight different
influenza strains expressing seven different
influenza A subtypes, compared to only 5 % of mice who received mock vaccinations.
Thus,
researchers need to cover a lot of ground before they can make accurate
influenza forecasts and give health officials detailed strategies.
As the climate heats up and warmer winters become more frequent,
researchers said, earlier
influenza seasons may become more common.
As controversy rages around the scientists who created mutant strains of the H5N1 avian
influenza virus, leading flu
researchers have called for a 60 - day voluntary pause on such work.
Researchers Graham Laver and Robert Webster discover that waterfowl are the natural hosts of
influenza viruses.
In collaboration with many
researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of
influenza; the impact of behavioral changes, long periods of infectiousness, variable infectivity, co-infections, prostitution, social networks, and vaccine efficacy on HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales for epidemics of foot and mouth disease.
To find out how the virus might spread among people, an international group of
researchers infected ferrets, which often stand as proxies for people in
influenza studies.
Researchers quickly discovered that the virus was a type of avian
influenza, known as H7N9, never before seen in humans.
In the largest nursing home study to date on the effect of high dose flu vaccine,
researchers found that shots with four times the strength of standard flu shots significantly reduced the risk of being hospitalized during the
influenza season.
The
researchers found 38 studies published between June 2011 and April 2016 that measured the effectiveness of the inactivated pandemic
influenza vaccines, covering a population of more than 7.6 m people.
Months after being infected with
influenza, mice had signs of brain damage and memory trouble,
researchers report online February 26 in the Journal of Neuroscience.
Researchers concluded that the high - dose vaccine is safe, induces significantly higher antibody responses, and provides superior protection against laboratory - confirmed
influenza illness compared to standard dose among persons over 65 years of age.
The
researchers also employed a cutting - edge technology developed by their collaborators at Columbia University to reprogram the child's skin cells into early progenitor cells, then differentiate those into lung cells, the front lines of
influenza infections.
For some
researchers the big goal is to bump up the effectiveness of existing vaccines, most of them made from chemically - killed
influenza particles or proteins extracted from such particles (see «Anatomy of a killer virus»).
In the animal model, the
researchers infected two groups of mice with a lethal dose of
influenza.
A team of Spanish
researchers looked at the effect of repeated
influenza vaccinations in the current and 3 previous seasons in people aged 65 years and older admitted to 20 Spanish hospitals in 2013/14 and 2014/15 to determine whether repeat vaccination reduced severe
influenza.
DNA from ancient microbes could also help today's medical
researchers keep one step ahead of fast - evolving diseases like cholera and
influenza.
«When we look at pandemic strains of
influenza that have high mortality rates, one of the best adaptations of those pandemic viruses is their ability to infect these alveolar epithelial cells,» explained
researcher Amber Cardani, PhD.
For their next steps, the
researchers are consulting with colleagues to determine if patients being treated with Accolate and Singulair are less likely to develop
influenza pneumonia during flu outbreaks.
Just as flu season swings into full gear,
researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the
influenza A virus.
As expected, the
researchers found that the group of participants who had high levels of anti-HA antibodies when enrolled in the trial experienced a significantly lower incidence of mild - to - moderate
influenza disease and some reduction in its duration compared with participants with low HA antibody levels.
Researchers are «now looking very carefully to see if they have in their freezers samples from pigs or other animals that might provide a missing link and information about intermediate viruses that could help narrow down the time and place of emergence of this novel
influenza virus,» said Cox.
Yale Cancer Center
researchers have developed a vaccine strategy that reduces the risk of flu infections in cancer patients at highest risk for
influenza.
Now,
researchers have come up with an alternative, faster strategy for when a pandemic
influenza virus surfaces: Just squirt genes for the protective antibodies into people's noses.
In earlier work, the
researchers developed a virus - killing nanoparticle coated in the sugar that the
influenza virus uses to invade lung tissue.
«We hope these results help
researchers better understand why asthmatics are more affected by
influenza and help find new treatments for common lung infections, which often make asthma symptoms worse.»
By developing a new technique for labeling the gene segments of
influenza viruses,
researchers now know more about how
influenza viruses enter the cell and establish cell co-infections — a major contributing factor to potential pandemic development.
The
researchers exploited vulnerabilities in the genetic material of
influenza viruses to create a weakened virus that can still kick - start the immune system.
There is a database called the
influenza sequence database that I believe is maintained at Los Alamos by a group of
researchers there and for some years now they have had an open part of it and a closed or private part of that database, and a small number of
researchers have been allowed to have access, small number of labs have been allowed to have access to this private database and they deposit their flu samples in there and they can share data amongst themselves, but no one else gets to look at it.
The specificity of the approach enabled the
researchers to visualize the delivery of the eight
influenza genome segments to the cell nucleus where the virus replicates, and to analyze co-infections by two
influenza viruses that differed by single mutations.
The current
influenza (flu) vaccination policy in England and Wales should be expanded to target 5 to 16 - year - olds in order to further reduce the number of deaths from flu, according to a study by UK
researchers published in this week's PLOS Medicine.
With very little scientific data available about the new strain, the MIT
researchers stress the need for better surveillance to track the outbreak and to help scientists to determine how to respond to this
influenza variant.