Sentences with phrase «influenza vaccine responses»

A study published on December 11th in PLOS Pathogens reports that genetic variants in a gene called IL - 28B influence influenza vaccine responses.

Not exact matches

This insight may help us improve vaccine responses in the elderly — a group at particular risk of diseases including influenza — by pre-treatment with anti-inflammatory agents.»

In collaboration with many researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of influenza; the impact of behavioral changes, long periods of infectiousness, variable infectivity, co-infections, prostitution, social networks, and vaccine efficacy on HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales for epidemics of foot and mouth disease.

A team led by Ron Dagan, a pediatric infectious disease specialist at Soroka University Medical Center in Beer - Sheva, Israel, wanted to know if a new pneumococcal vaccine based on tetanus toxoid would change infants» immune responses to the standard regimen of vaccines, including those for diphtheria, tetanus, pertussis (DTP), and Haemophilus influenzae type B, which protects against meningitis.

Back to the future: Immunization with M - 001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain.

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

Researchers concluded that the high - dose vaccine is safe, induces significantly higher antibody responses, and provides superior protection against laboratory - confirmed influenza illness compared to standard dose among persons over 65 years of age.

«The idea behind this study was to re-evaluate the bar that was previously established for evaluating a person's immune response to influenza vaccines,» said the study's principal investigator Matthew J. Memoli, M.D., director of the Clinical Studies Unit in NIAID's Laboratory of Infectious Diseases.

The influenza specific T - follicular helper cell response varied based on trimester of pregnancy in which the vaccine was given.

Vaccine immunology is poorly understood in pregnancy and Tfh cell expansion has been shown to be a predictor of response to influenza vaccination outside of pregnancy.

No data are yet available for trials in children, who typically have much less robust immune responses to the seasonal influenza vaccine and require a second dose.

And when they pre-treated immune cells from vaccinated major allele carriers with a molecule that inhibits the receptor that is normally stimulated by IL - 28B, they saw a stronger antibody response after the cells were stimulated with influenza vaccine.

The study, published in the Journal of Infectious Diseases and funded by vaccine - maker Sanofi Pasteur, found that — with the exception of one strain of flu circulating in the 2012 - 2013 season — the high dose flu vaccine helped participants mount a better immune response to influenza than the standard flu shot.

The degree of splitting could influence how the vaccine triggers an immune response, said one influenza vaccine expert who asked for anonymity.

The «primer» pandemic influenza vaccine — made from live but weakened virus — introduces the immune system to H7N9 influenza virus, and subsequent vaccination with the «booster» inactivated virus vaccine recalls a more robust immune response.

«Careful consideration of the complexity of influenza immune protection and evaluation of all aspects of the anti-influenza immune responses will ultimately be necessary in the development of a successful broadly protective or universal influenza vaccine,» the authors said.

In clinical trials, several candidate H7N9 pandemic influenza vaccines made from inactivated viruses have been shown to be safe and to generate an immune response.

Beyond the issue of alleviating real and potential shortages of influenza - vaccine supplies is the possibility of pursuing vaccination strategies that would induce optimal immunity among populations of persons who not only are at greatest risk for complications but who also generally do not mount an optimal immune response.

Specifically, 1 unit of access comprising a vaccination / challenge study with 3 groups of 6 ferrets (control and 2 vaccine groups), to include vaccination / boost, intra-nasal challenge with influenza virus, monitoring of virus load (nasal washes), disease progression and immune responses (antibody, IFN gamma ELISA and ELISpot).

Several candidate gene studies suggest that variations in HLA class 1 and other genes contribute to differences in antibody response to influenza vaccines [15], [69], [70].

A feasibility study: association between gut microbiota enterotype and antibody response to seasonal trivalent influenza vaccine in adults — Nick Shortt — Clinical and Translational Immunology

Genetic information about immune response to influenza could inform vaccine development and distribution, and disease treatment strategies [17], [67], [68].

Prof. Sarah Gilbert: I am the author of a patent on an influenza vaccine to induce broad immunity through T cell responses

Previous studies have also indicated that maternal Abs did not suppress infant Ab responses to H. influenzae type B vaccines (132).

«IL - 28B is a key regulator of B - and T - Cell vaccine responses against influenza» by Adrian Egli et al. published in PLOS Pathogens on Thursday 11 December 2014.

«The study by Egli et al. holds promise for enhancing the response of the seasonal influenza vaccine by blocking the receptor used for the innate immunity signalling molecule IL28B.

The unit of access comprises a vaccination / challenge study with 3 groups of 6 ferrets (control and 2 vaccine groups), to include intra-nasal challenge with influenza virus, monitoring of virus load (nasal washes), disease progression and immune responses (antibody, IFN gamma ELISA and ELISpot).

Kiecolt - Glaser JK, Glaser R, Gravenstein S, et al: Chronic stress alters the immune response to influenza virus vaccine in older adults.

Effects of zinc supplementation on the immune system and on antibody response to multivalent influenza vaccine in hemodialysis patients.

Kitikoon P, Nilubol D, Vincent A, Yu S, Erickson B, Janke B, Hoover T, Sornsen S, Thacker E. Immune response and effect of maternal antibody interference on vaccination with a bivalent swine influenza vaccine.

Live attenuated influenza vaccines have been shown to provide better immune responses to protect against influenza.

FLORHAM PARK, N.J., Sept. 9, 2014 — Zoetis has partnered with the renowned Gluck Equine Research Center at the University of Kentucky to show that FLUVAC INNOVATOR ®, the first equine influenza virus (EIV) vaccine, can provide a demonstrated cross-reactive immune response against emerging EIV strains.

His current research interest at University of Rochester focuses on the molecular biology, pathogenesis, innate immune responses and vaccine development for RNA viruses, mainly arenaviruses and influenza.

Evaluation of the ability of canarypox - vectored equine influenza virus vaccines to induce humoral immune responses against canine influenza viruses in dogs.

Guebre - Xabier, M., Hammond, S.A., Epperson, D.E., Yu, J., Ellingsworth, L., Glenn, G.M. Immunostimulant patch containing heat labile enterotoxin from E. coli enhances immune responses to injected influenza vaccine through activation of dendritic cells.

Researchers at the University of Birmingham in the United Kingdom, who studied married couples» antibody response to an influenza vaccine, found that people in satisfying marriages had stronger immunity to flu viruses.