Genetic information about immune response to influenza could
inform vaccine development and distribution, and disease treatment strategies [17], [67], [68].
The structure could
inform vaccine development, as the Zika E glycoprotein is a key target of immune responses against the virus.
Not exact matches
On the other hand, there was the potential to help
inform the
development of
vaccines and treatments down the road, because the decoy protein could interfere with treatments targeting the critical protein.
The findings may help
inform future
vaccine development and public health responses.
The researchers hope that understanding the level of virus needed for transmission of infection will provide a useful reference point for the
development of experimental drugs and
vaccines and could be used to
inform the endpoints for clinical trials evaluating such interventions.
This can
inform and accelerate the
development of new
vaccines, especially important during outbreaks and epidemics when clinical testing of
vaccine candidates need to be fast tracked.
This result can
inform and accelerate rational
development of other new
vaccines based on living viruses.
Ongoing trials will help
inform future
vaccine development,» said McCracken.
Col. Nelson Michael, the WRAIR Zika program co-lead, said, «This critical first step has
informed our ongoing work in non-human primates and gives us early confidence that
development of a protective Zika virus
vaccine for humans is feasible.»
Through her Clinical Team Grant, Dr. Bhardwaj and Sacha Gnjatic, Ph.D., are investigating the relationship between checkpoint immunotherapy, chemotherapy, and mutations in advanced bladder cancer, to guide
vaccine development and
inform combination treatment approaches.
A Regulatory Core with expertise to synthesize outputs to generate and disseminate classifications, guidelines, reference standards for
vaccine development, and
inform EFPIA activities.
«Now that we know that [the difference] exists, it contributes to our understanding of why the
vaccine is not effective in all cases and
informs future
vaccine development efforts,» said Dr. Dan Neafsey, associate director of the Genomic Center for Infectious Diseases at the Broad and co-first author of the study.
Understanding Zika's mechanisms will illuminate how viral infection leads to birth defects such as microcephaly, a condition marked by an abnormally small head and brain size, and could
inform the
development of therapies and
vaccines, the study authors said.