The researchers observed that TAAR1 was decreased in the region of the brain important for the process of decision - making and executive function (
infralimbic cortex) of the experimental models as compared to controls.
Doherty, J.M., Cooke, B.M., Frantz, K.J. (2013) Attenuated Fos immunoreactivity in prelimbic and
infralimbic medial prefrontal cortex during heroin - seeking behavior in adolescent vs. adult male rats.
Graybiel suspected the rats» habitual behavior was maintained by an area in the front part of the brain known as
the infralimbic (IL) cortex, believed to be involved in memory retrieval and habit performance.
The deactivation of specific PFC regions significantly altered the performance of the animals: The inhibition of regions in
the infralimbic cortex (IL) or the orbitofrontal cortex (OFC) impeded the ability of the rats to react to external signals.
These insights support the hypothesis that
the infralimbic cortex and the prelimbic cortex play an opposing role to that of the orbitofrontal cortex: While the IL and the PL direct proactive behavior in reaction to external signals, the OFC controls reactive behavior.
He said he'd next like to look at what other regions in the brain
these infralimbic cortex neurons may be communicating with.
Based on previous electrophysiology studies, Suto and his colleagues speculated that memories associated with these two lessons were both stored in a region of the brain called
the infralimbic cortex.
Intriguingly,
the infralimbic vmPFC inhibits stress - induced neural activity in the rodent brainstem and is important in facilitating escape and extinction learning (18, 26).