Primary immunodeficiency (PID)--
inherited immune disorders resulting from genetic mutations, usually present at birth and diagnosed in childhood.
«These results are an exciting early indication that this gene therapy is well tolerated and effective in infants as young as 2 months old with this devastating
inherited immune disorder,» said Ewelina Mamcarz, M.D., an assistant member of the St. Jude Department of Bone Marrow Transplantation and Cellular Therapy.
Not exact matches
The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an
inherited lipid storage
disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive
immune cells, called type II NKT - TFH, that promote the development of plasma cells.
George Daley of Harvard Medical School said on December 1 that he and his team have seen multiple patients affected by NEMO deficiency syndrome, a
disorder where an
inherited faulty gene results in a weak
immune system and leaves patients prone to serious infections.
Nearly 80 clinical trials have attempted to correct faulty disease - causing genes, but only treatments for
inherited immune - deficiency
disorders have shown any success.
Preliminary findings indicate gene therapy pioneered at St. Jude Children's Research Hospital is safe and effective for babies with a devastating
inherited disorder that leaves them with little or no
immune protection
Among the more common include: breed predisposition (
inherited),
immune mediated
disorders (caused by the animal's own
immune system), use of certain drugs, and some systemic diseases.
Dr. Messinger specializes in the diagnosis and treatment of all skin, coat, ear and nail diseases in animals, including bacterial, viral, fungal and parasitic infections, allergies,
immune - mediated skin diseases, endocrine (hormonal)
disorders,
inherited skin diseases, and certain skin cancers, to name a few.