Sentences with phrase «inhibit angiogenesis»

Inhibit angiogenesis, which prevents the growth of new blood vessels in breast cancer cells.

Any of these key steps can be a potential pharmacological target to inhibit angiogenesis and, hence, to treat angiogenesis - dependent diseases [9].

In the CAM assay, the inhibitory doses exhibited by kahweol are similar to those of other anti-angiogenic compounds found by us to inhibit angiogenesis in the CAM assay [10], [19], and much lower than those of other anti-angiogenic compounds [21].

Microtubule - targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.

Itraconazole Inhibits Angiogenesis and Tumor Growth in Non — Small Cell Lung Cancer.

In addition, they detoxify and neutralize carcinogens in the body, while inhibiting angiogenesis — the cancer - promoting growth of blood vessels that nourish tumors.

Some reasons why plant - based diets may be effective include lowering methionine intake, inhibiting angiogenesis, intercepting carcinogens, and increasing fiber and antioxidants.

Not exact matches

Mogroside V has been found in research to have the ability to inhibit tumor growth in pancreatic cancer by interfering with the rapid dividing of cancer cells, preventing angiogenesis (blood flow to the tumor), and even promoting cancer cell death (10).

The cannabinoids inhibited the expression of several genes critical to angiogenesis known as the VEGF (vascular endothelial growth factor) pathway.

Trebananib (formally known as AMG 386; Amgen) is a first - in - class peptide - Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

It was the first drug designed to inhibit new vessel growth (angiogenesis), and was approved by the FDA in 2004 for treating colorectal cancers — which typically boost angiogenesis to keep themselves well supplied with oxygen and nutrients.

Genentech, the drug's maker, has also developed a similar «eye - specific» angiogenesis - inhibiting, anti-VEGF monoclonal antibody, Lucentis (ranibizumab).

NK cells require active STAT5 to kill tumor cells; however, when STAT5 is absent or inhibited, NK cells do the opposite: they accelerate cancer progression by promoting angiogenesis.

Albeit still limited in efficacy, angiogenesis - inhibiting drugs have become part of standard tumor therapy supporting the efficacy of established chemotherapies.

However, it was not known how these cells produced the required energy and it was never considered to inhibit the energy production process in order to block angiogenesis.

Some cancer drugs inhibit secreted growth factors but have been only partially effective at blocking angiogenesis (SN: 6/7/03, p. 358: Available to subscribers at Cancer Advance: Treatment combinations stall colorectal cancer).

Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.

Research Paper Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis Yaqi Lv, Xiangmei Zhao, Lidan Zhu, Sijia Li, Qingqing Xiao, Wei He, Lifang Yin Theranostics 2018; 8 (10): 2830 - 2845.

On the other hand, the present research work shows a confirmatory evidence of the potential of kahweol to inhibit in vivo angiogenesis, by using another completely independent model system, namely, that of genetically modified zebrafish.

Our results indicate that kahweol inhibits two key inflammatory mediators, COX - 2 and MCP - 1, which are also related with angiogenesis.

A third line of evidence showing the potential of kahweol to inhibit overall angiogenesis is provided by the ex vivo model of the mouse aortic ring assay.

Fourth, vitamin C can inhibit tumor angiogenesis, the process of new blood - cell formation crucial to tumor survival.

Ricker JL, Chen Z, Yang XP, et al. 2 - methoxyestradiol inhibits hypoxia - inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.

Not only does milk thistle exert activity through inhibiting proliferation and angiogenesis, but also in response to epigenetic - influences — making it... Read More»

Not only does milk thistle exert activity through inhibiting proliferation and angiogenesis, but also in response to epigenetic - influences — making it an anti-cancer super star.

They inhibit tumor blood vessel formation (angiogenesis) and tumor cell migration (needed for metastasis).