Sentences with phrase «inhibit inflammation of»

A unique fatty acid called 1 - Tetradecanol complex inhibits inflammation of the gingival tissue.

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Studies have shown it to be useful in increasing synthesis of collagen and lipids, inhibiting the transfer of melanosomes and decreasing inflammation.

Lauric acid has not only been shown to inhibit the growth of bacteria that cause skin inflammation which leads to acne, but it also prevents the growth from antibiotic resistant bacteria.

In addition to the ACE - inhibiting peptides that we just discussed, high doses of whey protein have been found to reduce levels of C - reactive protein (CRP), a marker for inflammation.

They also inhibit the production of certain neurotransmitters, which increase pain and inflammation.

Curcumin can inhibit both the activity and the synthesis of cyclooxygenase - 2 (COX2) and 5 - lipoxygenase (5 - LOX), as well as other enzymes that have been implicated in inflammation.

To test whether this enzyme was to blame, they conducted a follow - up test with 18 of the over-65 participants, who took Losmapimod, a drug that inhibits the enzyme in order to reduce acute inflammation responses.

«If we can find ways to block or inhibit CD11b early on, we should be able reduce or limit the amount of abnormal leukocyte trafficking, inflammation, and the resulting demyelination and loss of axons in AIDP,» he said.

Professor Rudi Beyaert (VIB / UGent): «We found that pharmacological treatment of human skin cells with drugs that inhibit the activity of MALT1 reduced the production of inflammation promoting proteins caused by mutant variants of CARD14.

The therapies, hotly pursued by pharmaceutical companies, inhibit proteins called kinases, and aim to halt the inflammation that causes debilitating pain and eventual destruction of bone and cartilage.

Mongersen works by indirectly inhibiting inflammation caused by the immune protein TNF - alpha, researchers report in the March 19 New England Journal of Medicine.

«Our encouraging preliminary data suggest that the repurposed drug Vinpocetine may play a critical role in inhibiting inflammation and enhancing antimicrobial defenses in otitis media,» said Dr. Jian - Dong Li, director of the Institute for Biomedical Sciences at Georgia State and a Georgia Research Alliance Eminent Scholar in Inflammation ainflammation and enhancing antimicrobial defenses in otitis media,» said Dr. Jian - Dong Li, director of the Institute for Biomedical Sciences at Georgia State and a Georgia Research Alliance Eminent Scholar in Inflammation aInflammation and Immunity.

With this new understanding of how Del - 1 can inhibit periodontal bone loss — both by reducing inflammation and by restraining the activity of osteoclasts that resorb bone tissue — the researchers tested it, in a preclinical model of periodontitis observing that Del - 1 significantly reduced inflammation and tissue damage and that there was significantly less bone loss.

The Penn scientists demonstrated that applying Del - 1 to the gums can inhibit inflammation and bone loss in a mouse model of periodontitis.

In particular, drugs that inhibit production of prostaglandin E2 may curb inflammation and tumor growth, while avoiding the cardiovascular side effects of drugs such as Vioxx and the gastrointestinal problems of the earlier class of NSAIDs.

«The immortal fat cells are a great experimental tool that will allow us to investigate the mechanisms of the inflammation and allow us to test ways to potentially inhibit the response,» says Klingelhutz.

One group had undergone bypass surgery, the other PCI with a new generation of stent that is coated with the drug everolimus to inhibit inflammation and scar tissue growth.

In rheumatoid arthritis, abatacept inhibits T - cell activation and prevents the chain of events that lead to debilitating joint inflammation.

A team of scientists led by Stony Brook University researchers have discovered a new mechanism for a bacterial toxin to inhibit inflammation.

«Injecting cathelicidins inhibits the development of pancreatic inflammation and, as such, suppresses the development of autoimmune disease in these mice» states Julien Diana.

In 2012 research, she identified a mechanism for gamma - tocopherol increasing lung inflammation: protein kinase C - alpha, which binds both forms of vitamin E. Alpha - tocopherol inhibits the action of the protein and gamma - tocopherol increases the action of the protein.

The Nature paper further describes laboratory tests in which an existing anti-inflammatory inhibits caspase - 1, thereby preventing pyroptosis and breaking the cycle of cell death and inflammation.

By inhibiting p38 MAPK, it prevents both inflammation in the glial cells and disruption of the neuronal messages at the synapse.

Current TKIs inhibit the normal EGFR as well as the mutant EGFR, causing acne - like skin rashes and paronychia — an inflammation of the folds of tissue around finger and toe nails — both of which can be very troublesome for patients.»

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

A recent paper in the experimental biology publication The FASEB Journal describes how peptides found in hookworms inhibit the proliferation of effector memory T cells, which, unlike regulatory T cells, can actually trigger inflammation.

Inflammation provides a clue: Dietary restriction sharply inhibits the inflammatory response, and that may be part of why it promotes longevity at the same time that it reduces insulin resistance and slows dementia.

«Ind - Cl is just such a drug in that it inhibits selective inflammation of the central nervous system,» Tiwari - Woodruff added.

This means Ind - Cl not only inhibits inflammation but is capable of reducing axon degeneration and restoring neuronal function.»

«Our approach to use a combination treatment of DHCA and Mal - gluc to simultaneously inhibit peripheral inflammation and modulate synaptic plasticity in the brain works synergistically to optimize resilience against chronic stress - induced depression - like phenotypes,» said Dr. Pasinetti.

«Previously, we've delivered nanoparticles through the bloodstream and shown that they inhibit inflammation in a model of rheumatoid arthritis.

The researchers found glucocorticoids tightly control bacteria - induced innate immune and inflammatory response by enhancing IRAK - M, one of the most critical negative feedback regulators of inflammation that inhibits the activation of the proteins MyD88 and IRAK1 / 4.

Treating obese mice with CST inhibited the recruitment of monocyte - derived macrophages to the liver and decreased inflammation, suggesting CST is an anti-inflammatory peptide.

deCODE has in - licensed a compound, DG031, designed to inhibit FLAP, and the company has designed clinical trials to test its effectiveness in reducing key measures of inflammation and in preventing heart attack.

Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J. «Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model».

deCODE's findings suggest that inhibiting the activity of FLAP may thus be an effective means of reducing inflammation and thereby preventing the development of heart attack and stroke.

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

The two labs are now collaborating on further studies of the new enzymes — and the potential benefits of inhibiting them — in mouse models of diabetes, inflammation and autoimmune disease.

A number of studies reported that HDAC inhibitors could suppress the immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit immune rejection or induce tolerance in organ transplantation and BMT (20 — 23).

LONDON (July 16, 2017)-- Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance.

In the second set of experiments, we will use a genetically modified virus to deliver a gene known to inhibit inflammation in the eye.

In this study, we used similarity - based virtual screening and molecular docking analysis to identify a RIPK2 inhibitor that can empirically inhibit the autophosphorylation of RIPK2, inhibit NFκB, and alleviate lung and intestinal inflammation efficacious at 1 — 2 μg / g body weight.

Interestingly, RIPK2 inhibitor 1 can also inhibit the activation of hypoxia - response element I response to chemical induction using 1 % H2O2 (Supplemental Fig. 3C) to suggest either a link to inflammation or a direct modulation of hypoxia - inducible factor α function.

Due to their high content of flavonoids, lemons reduce inflammation and inhibit the growth of cancer cells.

The antibacterial compounds in bananas inhibit the growth of ulcer - causing H. pylori and wipe out the acidity of gastric juices, which helps reduce inflammation and strengthen the stomach lining.

It works by inhibiting the calcium - induced inflammation pathways of cells.

It's rich in antioxidants, potent phytonutrient glucosinolates and contains compounds known as bioflavonoids such as kaempferol which combat inflammation by cooling the body and inhibiting the effects of oxidative stress and weight gain.

Oleic acid improves blood circulation, normalizes cholesterol and glucose levels, packs an abundance of antioxidants, inhibits the growth of cancerous cells and reduces inflammation all over the body, all of which make it a potent tool for preventing diabetes, cancer and other serious diseases.

It has the potential to inhibit the COX - 2 enzyme, the same as ibuprofen, decrease inflammation and accelerate the healing of injuries.

One of the most inflammation - causing genes is COX - 2, and scientists have worked for decades to discover a drug that can inhibit it.