Sentences with phrase «inhibit microtubule»
After entering axons through activated TRPV4 channels, calcium ions appear to disrupt the microtubule cytoskeleton by inhibiting a microtubule - stabilizing protein called STOP.
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The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Not exact matches
When the researchers administered drugs to inhibit the movement of certain «motor» proteins that transport mitochondria and other cargo within the cell by traveling along microtubules, the mitochondria accumulated in the axon of the neuron and never made it to the synaptic terminal.
A compound, adociasulfate - 2, was isolated from a marine sponge, Haliclona (also known asAdocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule.
A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.
Microtubule - targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.
These agents disrupt the microtubule cytoskeleton, thereby inhibiting the attachment of chromosomes to the mitotic spindle and activating the spindle assembly checkpoint (SAC), a surveillance mechanism that delays the progression of cell division.
The monopolin complex regulates different types of kinetochore - microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schizosaccharomyces pombe mitosis.