Sentences with phrase «inhibit tumorigenesis»

Embryonic stem cells (ESCs) represent a source for the large numbers of modified EPCs required to therapeutically inhibit tumorigenesis [3], although patient - specific induced pluripotent stem cells (iPSCs) represent a more attractive option.

«We found that AIM2 inhibits tumorigenesis in multiple animal models of colorectal cancer by restricting the pro-survival signaling molecule, Akt, which is commonly hyperactive in many human cancers.»

Cancer studies have increasingly focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.

Not exact matches

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

Activated Abl kinase inhibits oncogenic transforming growth factor - β signaling and tumorigenesis in mammary tumors.

Can MDM2 itself be inhibited in unique ways to reactivate TP53 and suppress tumorigenesis?

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

Dr. Charron's research focuses on understanding how medulloblastoma forms, in particular which genes may promote or inhibit medulloblastoma tumorigenesis.

Ellagic acid inhibits N - nitrosomethylbenzylamine (NMBA) tumorigenesis in the oesophagus of F - 344 rats.

Ellagic Acid efficacy to inhibit lung tumorigenesis induced by NNK.