Sentences with phrase «inhibited by neurons»

The scientists discovered that a class of mechanoreceptors in the skin that detect painful mechanical stimuli are part of a feedback circuit in which excitatory neurons that produce the hormone somatostatin are inhibited by neurons that synthesize dynorphin (a natural analgesic molecule that produces effects similar to opiates).

Not exact matches

If we compare the power I exercise by way of sound waves upon your ears (power, sense 1) with the power that I, in action, exercise upon some neuron that fires or is inhibited from firing during the action (power, sense 2), we see a marked difference.

It is considered an inhibitory neurotransmitter, which means it regulates brain and nerve cell activity by inhibiting the number of neurons firing in the brain.

Both drugs inhibit reuptake, or reabsorption, of these neurotransmitters by neurons, thus prolonging their action.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

That suggested that it might induce sleepiness by inhibiting the activity of those neurons.

When the researchers administered drugs to inhibit the movement of certain «motor» proteins that transport mitochondria and other cargo within the cell by traveling along microtubules, the mitochondria accumulated in the axon of the neuron and never made it to the synaptic terminal.

The first effective drug for epilepsy, potassium bromide, was introduced in the 1850s and works by inhibiting the excitability of neurons.

Moreover, the pharmacologists were able to demonstrate that neurons on the superficial layers of the spinal cord, where the relay of the pain signals takes place, are primarily inhibited by glycine signals.

Neuronal cell - glial cell adhesion was inhibited by prior incubation of the neurons with Fab» fragments of antibodies to neuronal membranes.

«We were able to abolish sociability by inhibiting these neurons and we could magnify and prolong sociability by turning them on,» said Anderson.

Interestingly, by recording the electrical activity in the spinal cords of mice depleted of NPY interneurons, the researchers discovered that the NPY neurons seem to selectively inhibit or gate light touch signals coming from hairy skin, but not the non-hairy (glabrous) skin, such as the skin found on your palm.

«By interfering with the activity of sensory neurons, we may be able to inhibit multiple types of itching,» said principal investigator Zhou - Feng Chen, PhD, director of the university's Center for the Study of Itch.

Furthermore, the effects of CC2D1A depletion in neurons could be reversed by treating the mice with compounds that inhibit NF - kappaB activity.

Although the genetic links between norepinephrine and its receptors and transporters are not as clearly understood as those for dopamine, medications such as atomoxetine that inhibit norepinephrine reuptake by neurons do improve symptoms.

So Lovejoy and his colleagues used monkeys and a drug called muscimol, which safely shuts down parts of the brain by inhibiting neurons where it is injected.

The UAB researchers, led by corresponding author John Hablitz, Ph.D., professor and interim chair of Neurobiology, UAB School of Medicine, found that treatments that inhibit DNA methylation in cultured rat neocortical neurons caused an increase in the IME of those neurons, as shown by an increased frequency of a series of action potentials when the neurons were stimulated.

But the neuron first remained inhibited for a longer time, and that time overlapped with the time the cell was excited, which had the effect of suppressing the signal emitted by the brain cell.

Disrupting locomotion by inhibiting motor neurons of a worm with laser light from Samuel Lab on Vimeo.

Through studying the brains of these mice, the team uncovered that the faulty gene inhibits neurons, by releasing excess of the neurotransmitter GABA.

Optogenetics has taken neuroscience by storm in recent years because the technique allows scientists to study the brain conveniently in animals, activating or inhibiting selected groups of neurons at the flip of a switch. Most often, scientists use a fiber optic cable to deliver light into the brain.

«Our findings suggest that apoE4 inhibits the development of newborn neurons by impairing specific signaling pathways and that boosting these pathways with drugs may be of therapeutic benefit,» said Dr. Huang.

In terms of pathogenic mechanisms of PD, given that miR - 181a is selectively up - regulated in nigrostriatal DA neurons of the PD brain [13], our current findings suggest that this up - regulation in miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivo.

10 % of MBH NPY neurons were inhibited by l - leucine, and leucine rapidly reduced AGRP secretion, providing a mechanism for the rapid leucine - induced inhibition of foraging behavior in rodents.

The first, cholinesterase inhibitors, act by inhibiting the breakdown of the neurotransmitter, or neuron - to - neuron chemical messenger, acetylcholine.

WHAT TO AVOID TO HELP PREVENT ALZHEIMER»S DISEASE • STATIN DRUGS: Cholesterol is a vital part of the myelin sheath insulating neurons and assisting in propagation of nerve impulses; metabolites in the cholesterol biosynthesis pathway inhibited by statins are required to produce CoQ10 as well as functional GLUT4s.

The messengers are then captured by the next neuron, and can either excite or inhibit it depending on their chemical makeup.

First, by interacting with CB1 receptors, the endogenous cannabinoids released will help inhibit the firing of cAMP into succeeding neurons.