Sentences with phrase «inhibited by the antibodies»

Not exact matches

Denosumab, a fully human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.

In a collaborative project with several project partners and funded by the European Union and the Deutsche Forschungsgemeinschaft novel Sclerostin - inhibiting antibodies were generated and analysed for their suitability as osteoporosis treatment option.

First clinical trials with a Sclerostin - inhibiting antibody developed by the companies Amgen and UCB showed promising results in that the bone mass of participants suffering from osteoporosis increased.

Splicing in vitro of a messenger RNA (mRNA) precursor (pre-mRNA) is inhibited by a monoclonal antibody to the C proteins (anti-C) of the heterogeneous nuclear RNA (hnRNA)- ribonucleoprotein (hnRNP) particles.

Neuronal cell - glial cell adhesion was inhibited by prior incubation of the neurons with Fab» fragments of antibodies to neuronal membranes.

And when they pre-treated immune cells from vaccinated major allele carriers with a molecule that inhibits the receptor that is normally stimulated by IL - 28B, they saw a stronger antibody response after the cells were stimulated with influenza vaccine.

Funded by grants from the National Institutes of Health, scientists at Blood Systems Research Institute (BSRI) in San Francisco and the Washington University School of Medicine in St. Louis have found that neutralizing antibodies that engage epitopes including residue E2 - W64 are highly potent at inhibiting the virus in mice, due to the importance of E2 - W64 in pathogenicity.

Researchers carried out the study by chemically inhibiting the production of antibody - producing white blood cells (B lymphocytes) in broiler chicks, before introducing C.jejuni infection at the age of three weeks and then monitoring bacteria levels in the gut for the next nine weeks.

Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial cells into transporting the antibody across the blood - brain barrier.

Sperm - ZP binding was largely inhibited by glycoconjugates terminated with sialyl - Lewisx sequences or by antibodies directed against this sequence.

[i] Furthermore, [we] demonstrated that an MHC like molecule, called CD1d, loaded with a glycolipid ligand, called alphaGalCer, also targeted to the tumor cells by monoclonal antibodies, was capable to specifically inhibit tumor growth in vivo and to give a sustained activation of the Natural Killer Cells known to be important in the innate immunity.

The immune responses will be evaluated in the different species by measuring influenza antigen - specific IgG / IgA and IgM, neutralising antibodies and antibodies inhibiting hemagglutination and antigen specific lymphocyte responses and cytokine secretion profiles by advanced flow cytometry.

The rationale for using CT - 011, an immunotherapy antibody that blocks the programmed death (PD)-1 receptor, is to boost the function of the immune system by inhibiting PD - 1 whose function, in part, is to inhibit T - cell response.

We hypothesised that this antibody, directed against the substrate rather than the enzyme, could inhibit cleavage of AβPP by β - secretase via steric hindrance and thus reduce downstream production of Aβ.

By targeting antigens to B cells using monoclonal antibodies, he successfully inhibited the development of multiple sclerosis in an animal model.

There are potent medication creams and injections called biologics or monoclonal antibodies that work by inhibiting TNF - alpha's inflammatory effects.