Sentences with phrase «inhibiting mtb»
The alterations of the rifampin binding site prevent rifampin from binding to and inhibiting Mtb RNAP, preventing rifampin from killing TB bacteria.
https://www.sciencedaily.com/
The results reveal the interactions between Mtb RNAP and rifampin, reveal the mechanism by which rifampin inhibits Mtb RNAP, and enable rational, structure - based design of improved rifampin derivatives for inhibition of Mtb RNAP.
The results show that AAPs inhibit Mtb RNAP through a binding site that does not overlap the rifampin binding site and thus can inhibit rifampin - resistant Mtb RNAP and kill rifampin - resistant TB bacteria.
In addition, the Rutgers scientists report the discovery and properties of new, non?rifampin?related compounds — Na - aroyl - N - aryl - phenylalaninamides (AAPs)-- that potently and selectively inhibit Mtb RNAP and potently and selectively kill TB bacteria.They also report the structures of Mtb RNAP bound to an AAP and Mtb RNAP bound to both an AAP and rifampin.