Sentences with phrase «inhibiting cell cycle progression»

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

Not exact matches

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

Pax - 7 up - regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self - renewal.

While during S phase the cell automatically suppresses Cyclin D1 formation because it has the ability to inhibit DNA synthesis which may block the cycle progression and lead to the cell - arrest in this position [9].

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.