Sentences with phrase «inhibiting effector»
Therefore, in both mice and non-human primates, HO - 1 inducers delivered locally inhibited effector T - cells in an antigen - specific manner, paving the way for repositioning these drugs for the treatment of immune - mediated diseases.
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A recent paper in the experimental biology publication The FASEB Journal describes how peptides found in hookworms inhibit the proliferation of effector memory T cells, which, unlike regulatory T cells, can actually trigger inflammation.
Innate immune effector cells, including natural killer cells, macrophages, and dendritic cells, have been shown to interact with cancers and inhibit their progression.
Here we show that HO - 1 inducers inhibit antigen - specific effector T cells when injected intradermally together with the T cell cognate antigens in mice.
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8 + T cells.
The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process
Several studies have also suggested that OX40 signals can directly prevent suppressive activity of nTreg and can inhibit the induction of iTreg which further aid the clonal expansion and differentiation of effector T cells.
Because the same pool of naïve T cells can differentiate into inflammatory effector T cells or inhibitory Tregs, generation of immune responses requires promoting the differentiation of inflammatory T cells while reciprocally inhibiting the formation of Tregs.