Sentences with phrase «inhibiting tyrosine kinases»
Not exact matches
Although the enzyme itself is inhibited in this state, it can be more easily re-activated through other tyrosine kinases.
https://www.sciencedaily.com/
Therefore, a team led by Vladimir Tesar, MD, PhD (Charles University and General University Hospital, in the Czech Republic) tested the potential of an investigational drug called bosutinib that inhibits a particular tyrosine kinase called Src / Bcr - Abl.
Previous research from the TNP has shown that when tyrosine kinases are inhibited, the garbage disposal system begins working, allowing cells to once again clear toxic proteins.
It inhibits two tyrosine kinase enzymes called Jak1 and Jak2, which rev up production of immune cells.
In addition to being integral to cell biology, tyrosine kinases also present targets for new anticancer therapies: One of the most highly touted, rationally designed anticancer compounds, Gleevec, inhibits an oncogenic tyrosine kinase whose aberrant activity fuels the rampant growth of cells in patients with chronic myeloid leukemia.
Druker also led the original clinical development of Gleevec, which inhibits a biological switch called a tyrosine kinase that is abnormally activated in CML.
The adenosine triphosphate (ATP)-- competitive kinase inhibitors imatinib (STI571; trade name: Gleevec), dasatinib, and nilotinib inhibit multiple tyrosine kinases in addition to ABL1 and ABL2 (5).
RIPK2 inhibitor 2 appears to inhibit 38 % of the activity of SNARK and 27 % of the activity of FGFR2, GSK3 - β, JNK1, CSNK1G2 (casein kinase 1), and MET tyrosine kinase.
One of soy's primary isoflavones, genistein, has been shown to inhibit the enzyme tyrosine kinase in the brain.
Genistein Inhibits Both Estrogen and Growth Factor — stimulated Proliferation of Human Breast Cancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consuming soy.