Sentences with phrase «inhibition of acidification»

In fact, we found the inhibition of acidification of endosomes enhances the effect of conventional chemotherapy in mice, «says Dr. Lluís Espinosa.

Not exact matches

The experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and specifically inhibits the growth of cancer cells with mutant BRAF, both in vitro and in vivo.

Concordantly, inhibition of the cGMP - dependent protein kinase G (PKG) blocks egress induced by PKAc1 inactivation or environmental acidification, while a cGMP - phosphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisation.