Sentences with phrase «inhibition of adenosine»
[1,5,7] The direct inhibition of cdks 1, 2, and 4 via competitive inhibition of adenosine triphosphate binding by flavopiridol has been demonstrated.
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This study also linked adenosine inhibition to reduced brain plasticity and the end of efficient auditory learning.
In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.
For instance, we previously demonstrated that DGKζ - deficient T cells demonstrate partial insensitivity to several important mediators of immune inhibition within the tumor microenvironment, including PGE2 (12), adenosine (12), TGF - β (13), and PD - L1 (10).
«These preclinical results show the potential of our compound to target the inhibition of the A2A receptor in the challenging context of tumor - like adenosine concentrations.