Sentences with phrase «inhibitor palbociclib»
Mass spectrometry ‐ based cellular thermal shift assay (MS ‐ CeTSA) analysis of CDK4 / 6 inhibitor palbociclib targets in MCF7 human breast cancer cells identifies protein complexes including the 20S proteasome.
http://emboj.embopress.org/
Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4 / 6 inhibitor palbociclib, The EMBO Journal (2018).
Not exact matches
While MEK inhibitors are part of treatment protocols for melanoma, palbociclib is entering clinical trials for use in melanoma populations.
While one drug, MEK inhibitor, is usually used in advanced - stage melanoma, the other drug, CDK4 / 6 inhibitor, palbociclib, is currently FDA - approved for treatment of Estrogen Receptor - positive breast cancer patients.
«Our work suggests that proteasome inhibitors and palbociclib are a not a good combination, given that they act in opposite directions,» says Professor Matthias Trost of the Institute of Cell and Molecular Biosciences at Newcastle University, who co-led the study.
The proteasome is a novel downstream target for the anti ‐ cancer drug palbociclib inhibiting proliferation by reduced proteasomal association with its inhibitor EMC29.
Proteasome activation is required for palbociclib ‐ induced cellular senescence, which is sensitive to the proteasome inhibitor bortezomib.