Sentences with phrase «inhibitors on cancer cells»

He also investigates the effects of 2HG inhibitors on cancer cells.

Not exact matches

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» GreeneCancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greenecancer cell lines,» Greene said.

Figure on the left: Analyzing the relative sensitivity of hundreds of cancer cell lines to commonly used anti-cancer drugs (each dot) reveals that cells with suppressed expression of one proteasome cap subunit are specifically resistant to treatments with the proteasome inhibitors MG132 and bortezomib.

In collaboration with Prof. Dr. Roland Schüle and his team at the Center of Clinical Research of the Freiburg University Medical Center, the scientists were able to test several epigenetic inhibitors that had been newly developed by Schüle and his team on the cancer stem cell model.

PARP inhibitors target and block proteins which cancer cells depend on to repair DNA for their survival.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1.

«These inhibitors not only target cancer cells but may also have a negative impact on the immune system and NK cells.

In addition, if genifitib, an inhibitor to EGFR itself on the market for lung cancer, is added to the cell, the cells die.

Most integrin inhibitor drugs target their adhesive function and block them on the surface of the cancer cell.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

Since then, other checkpoint inhibitors have been developed and commercialised to block a T - cell receptor called PD - 1 or its ligand PD - L1, present on some normal cells as well as cancer cells.

Matriptase and its cognate inhibitor, HGF activator inhibitor 1 (HAI - 1) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu, suggesting that the inhibitor serves to prevent undesired proteolysis in these cells.

«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.

Title: BRCA1 - deficient mammary tumor cells are dependent on EZH2 expression and sensitive to PCR2 - inhibitor DZNep Authors: Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen - Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM Date: 2009 Publication Details: Breast Cancer Research 2009, 11: R63 doi: 10.1186 / bcr2354

Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents, on human lung cancer cells».

A new class of inhibitors offers a novel way to treat lung cancer with minimal toxic side effects on normal cells, according to a laboratory study funded through philanthropic contributions to the Lung Cancer Mooncancer with minimal toxic side effects on normal cells, according to a laboratory study funded through philanthropic contributions to the Lung Cancer MoonCancer Moon Shot.

Also, a 2012 study published on the Medical Journal 3 Biotech shows that the anti-cancer compounds in mushrooms play a crucial role as a reactive oxygen species inducer, mitotic kinase inhibitor, antimitotic, angiogenesis inhibitor, topoisomerase inhibitor all leading to apoptosis (cell death) and eventually checking cancer cell proliferation (4).