Sentences with phrase «inhibits apoptosis»

IGF - 1 (Insulin - Like Growth Factor 1) growth hormone links calorie restriction and longevity and inhibits apoptosis of cells.

Akt stimulates glucose uptake, glycogen synthesis, and protein synthesis via Akt / mTOR and Akt / GSK -3 β signaling networks and inhibits apoptosis and protein degradation in skeletal muscle by inactivating FoxO transcription factors leading to increased lean mass.

Upregulation of Bcl2 inhibits apoptosis - driven BAX insertion but favors BAX relocalization in mitochondria

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

In upcoming investigations, the scientists want to verify their findings on the development of liver cancer and search for active substances that inhibit apoptosis while simultaneously causing the mildest possible side effects.

Independent of MMP activity, TIMP - 1 can promote growth and inhibit apoptosis through various pathways, including P13K and PKA [9] and, furthermore, TIMP - 1 is able to provide β cell - specific pro-survival effects [5, 6, 10].

Indeed, insulin plays many vital roles in the brain: it mediates neuronal growth and metabolism, neurotransmission, and synaptic plasticity; promotes neuronal survival by inhibiting apoptosis; and regulates cognition and memory.

Not exact matches

Goji's are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis.

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

In a related finding that year, Michael Karin and his collaborators at the University of California, San Diego, found that inhibiting NF - kB in mice engineered to develop colitis, which can lead to colon cancer, also promoted apoptosis.

Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell - survival proteins (survivin, Mcl - 1, XIAP or cIAP2).

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

These compounds have been shown to inhibit cancer cell growth, induce cancer cell apoptosis, and reduce tumor volume in mice (14, 15, 16, 17).

MicroRNA - 93 inhibits inflammatory responses and cell apoptosis after cerebral ischemia reperfusion by targeting interleukin - 1 receptor - associated kinase 4.

Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic ß - Cells Is Inhibited by Unsaturated Oleic Acid.

Effects of miR -145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.

Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.

GCP, a genistein - rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines.

Furthermore, niclosamide inhibited not only signal transduction, but also targeted mitochondria in cancer cells resulting in cell cycle arrest, growth inhibition and apoptosis [49 - 51].

The benzamidazole mebendazole significantly inhibited growth of adrenocortical carcinoma cells, both in vitro and in vivo, the effects being due to induction of apoptosis [19].

Dual Blockade of PKA and NF — $ ąppa $ B Inhibits H2 Relaxin - Mediated Castrate - Resistant Growth of Prostate Cancer Sublines and Induces Apoptosis.

A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium.

Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.

Two newly synthesized 5 - methyltetrahydrofolate - like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1 / S phase and apoptosis in vitro.

Phthalates inhibit tamoxifen - induced apoptosis in MCF - 7 human breast cancer cells.

Moreover, annexin V / propidium iodide staining showed that VPA only marginally decreased the viability of in vitro — differentiated Th1 and Th17 cells at a relatively high concentration (1 mM)(Supplemental Fig. 4A, 4B), whereas VPA readily inhibited the differentiation of Th1 and Th17 cells at a low concentration (0.2 — 0.5 mM), indicating that apoptosis induction was not the primary mechanism for Th1 and Th17 cell differentiation inhibition (28, 29).

STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT - 29 cells.

Rasul A, Ding C, Li X, Khan M, Yi F, Ali M and Ma T. Dracorhodin perchlorate inhibits PI3K / Akt and NF - kappaB activation, up - regulates the expression of p53, and enhances apoptosis.

Actinomycin D (ActD), an antineoplastic antibiotic isolated from Streptomyces sp., has been reported to induce cytotoxicity and apoptosis, and inhibit growth of pancreatic cancer cells [11].

Kleeff J, Kornmann M, Sawhney H and Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells.

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

The drugs reduce pain and inflammation by inhibiting the cyclooxygenase (COX) enzymes, which are involved not only with inflammation but also with certain processes involved in cancer, such as blood supply to the tumor and programmed cell death (known as apoptosis).

Prosapogenin A, a saponin from Chinese herb Veratrum nigrum (black false hellebore or Li Lu in Chinese herbalism), could inhibit cell growth and promote cell apoptosis.

[10] Methyl jasmonate, a plant stress hormone produced by many plants including rosemary, olive, and ginger, inhibits HK, triggering apoptosis in cancer cells.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3 - L1 adipocytes.

Sunflower seeds are also a good source of selenium, which has been shown to induce DNA repair and synthesis in damaged cells, to inhibit the proliferation of cancer cells, and to induce their apoptosis, the self - destruction mechanism the body naturally produces to eliminate worn out or abnormal cells.

A study published in the Journal of Agricultural and Food Chemistry showed that in addition to strawberries, blueberries and black raspberries, blackberries, cranberries and red raspberries also had anti-cancer benefits, inhibiting cancer growth and stimulating cancer cell apoptosis in vitro.

The authors suggest a mechanism whereby HMB inhibits inflammation and muscle apoptosis in these populations, as well as improving protein synthesis and decreasing protein degradation, which results in increasing lean mass.

The drugs used in chemotherapy are designed to be toxic to cancer cells usually by inhibiting cell division or causing cell suicide (apoptosis).

We found that ellagic acid at a concentration of 10 -LRB--5) M induced G arrest within 48 hours, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 hours of treatment.

They also act aggressively against cancer by preventing cancer cell proliferation, inducing apoptosis — or cancer cell «suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.

This is extremely problematic, as melatonin inhibits the proliferation of a wide range of cancer cell types, as well as triggers cancer cell apoptosis (self - destruction).

Polyphenols have also been found to induce apoptosis and inhibit tumor proliferation, according to studies.

Green tea reduces C - reactive protein and green tea catechins can successfully banish cancer cells, by slowing metastasis, inhibiting cell proliferation and inducing apoptosis.

CB2 cannabinoid agonists such as WIN55,212 - 2 inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by mediating apoptosis of the encephalitogenic cells that induce brain inflammation (41).

RemedyLink Ellagic Acid contains a blend of USP grade ellagic acid and specific herbs which offer many health benefits, some of which include inhibiting fungi and yeast growth, killing bacteria, promoting the apoptosis of certain cells, and more.

In addition to helping you fall asleep and bestowing a feeling of overall comfort and well being, melatonin has proven to have an impressive array of anti-cancer benefits.4 Melatonin inhibits the proliferation of a wide range of cancer cell types, as well as triggering cancer cell apoptosis (self destruction).