Sentences with phrase «inhibits cell»

In the model estrogen - independent breast cancer, lunasin and aspirin administration inhibits cell proliferation, arrest cell cycle in S - phase as well as a decreases expression of cancer genes.

As with the ketogenic diet, caloric restriction also reduces oxidative stress, reduces inflammation and inhibits cell death.

It inhibits cell replication, changes membrane structure, reduces the size of villi that absorb nutrients, and increases secretions that cause oxidative damage.

p53 inhibits cell division primarily through a p21 pathway, involving proteins such as the cyclinD / CDK4 complex; the retinoblastoma protein (Rb), and the E2F protein [25,26].

The antiviral restriction factor IFN - induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans.

ActD inhibits cell proliferation by forming a stable complex with DNA duplexes via deoxyguanosine residues, resulting in the inhibition of RNA synthesis by blocking the elongation of RNA chains [12].

Fukami - Kobayashi J, Mitsui Y. Cyclin D1 inhibits cell proliferation through binding to PCNA and CDK2.

8/7/2008 Researchers Discover How Tumor Suppressor Inhibits Cell Growth Genes that inhibit the spontaneous development of cancer are called tumor suppressor genes.

Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin - 1 in cervical cancer cells.

Ectopic expression of DDX3 inhibits cell growth.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

MiR - 514a - 3p inhibits cell proliferation and epithelial - mesenchymal transition by targeting EGFR in clear cell renal cell carcinoma.

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF - 7 human breast cancer cells.

Chen, L., Gu, J., Xu, L., Qu, C., Zhang, Y., Zhang, W. (2014) RNAi - mediated silencing of ATP - binding cassette C4 protein inhibits cell growth in MGC80 - 3 gastric cancer cell lines.

MicroRNA - 33b inhibits cell proliferation and glycolysis by targeting hypoxia - inducible factor - 1a in malignant melanoma.

Green spots indicate a transcription factor that accumulates and inhibits cell division upon DNA damage.

They found that the cell recycling machinery is regulated by a protein called WHAMM, and that interfering with this protein or actin polymerization itself severely inhibits the cell's ability to recycle misfolded proteins and damaged organelles via autophagy.

The activation of the YAP protein induces uncontrolled cell growth and inhibits cell death, causing malignancies.

Another study looked specifically at small yellow onions, finding that their anti-inflammatory effects selectively inhibited cell growth.

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

Propylene glycol, in particular, has been known to inhibit cell growth and has been linked to kidney damage and liver abnormalities.

Smith's group was one of the first to report the existence of a protein called SDI, better known as p21 — which helps inhibit a cell's DNA synthesis and thus initiates its entry into senescence — and Pereira - Smith worked with him on the project.

Increased ceramide activity, in turn, inhibits cells that would normally produce VEGF and encourage blood vessel growth.

Cancer cells have runaway growth, so the researchers thought the compound might inhibit those cells.

A Johnson & Johnson research team identified a new compound known as R207910 that kills the M. tuberculosis bacterium by inhibiting the cell's energy - producing machinery.

Various receptors which can either activate or inhibit the cell have been identified on cell surface.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

In this cell type, bazedoxifene also potently inhibited cell growth.

DEET seems to work by inhibiting cells on an insect's antennae, dulling its ability to locate prey.

Through live cell imaging, they were able to identify a new triarylmethane compound that can rapidly inhibit cell division in plant cells.

«With the help of animal biologists, we found that chem7 had no effect on budding yeasts and human cells, which indicates that chem7 does not inhibit the cell division of animal cells.»

We started this research about 3 years ago, but we were fortunate to be able to identify a triarylmethane compound that can rapidly inhibit cell division in plants,» he continues.

«As part of ITbM's interdisciplinary research initiative, we decided to search for new compounds that can inhibit the cell division in plants without causing damage to them,» says Minako Ueda, a plant biologist and a leader of this study.

«Through the collaboration with chemists and biologists, we were fortunate to discover a new compound that can selectively inhibit the cell division of plant cells regardless of the cell phase,» says Ueda and Nambo.

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

Initially, fluoxetine protects bone by inhibiting the cells in the skeleton (osteoclasts) that constantly break down and resorb bone.

As an initial focus, researchers at Chicago will search for novel ways to take advantage of steroid hormones and their receptors to detect metastases, define their boundaries and deliver treatments directly to tumor cells in order to inhibit cell division or promote cell death.

Paull and Whikehart [7] have also shown that p53 and TAp63 (a p53 family member) are relatively elevated in the normal central human corneal endothelium suggesting that these proteins inhibit cell - cycle promotion from the G1 to S phase.

The researchers showed that the malacidins work differently from daptomycin and friulimicin, which kill bacteria by disrupting cell membranes and inhibiting cell wall biosynthesis, respectively.

Taxanes inhibit cell division and make cancer cells sensitive to radiation therapy.

Similar indolone compounds had been found to inhibit cell death but were toxic at higher concentrations.

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

In addition, RIPK2 inhibitor 1 appeared to also inhibit cell proliferation as determined by MTT assay, which did not appear to promote cell death.

They show that GABA inhibited the cells and reduced the secretion of a large number of inflammatory molecules.

There is even some research showing that beta - sitosterol may inhibit cell division of cancerous cells.

Further, in the presence of infection, fluoride inhibited the cells» production of superoxides — compounds that the cells normally employ against the challenge of a pathogen — thereby crippling white blood cells» healthy response.29

Both resolvin D1 and 1alpha, 25 - dihydroxyvitamin D3 improved the capability of the Alzheimer's patients» immune cells to gobble - up amyloid - beta, in addition they inhibited the cell death that's caused by amyloid - beta.

Prosapogenin A, a saponin from Chinese herb Veratrum nigrum (black false hellebore or Li Lu in Chinese herbalism), could inhibit cell growth and promote cell apoptosis.

They end up blocking circulation, damage heart action, inhibit cell renewal and impede the free flow of blood (and thus oxygen) and lymph fluids.

For starters, I've already mentioned that they cause oxidative cell damage which directly damages the cell mitochondria and inhibits your cells ability to utilize thyroid hormone properly.