Sentences with phrase «inhibits cell proliferation»

In the model estrogen - independent breast cancer, lunasin and aspirin administration inhibits cell proliferation, arrest cell cycle in S - phase as well as a decreases expression of cancer genes.

ActD inhibits cell proliferation by forming a stable complex with DNA duplexes via deoxyguanosine residues, resulting in the inhibition of RNA synthesis by blocking the elongation of RNA chains [12].

Fukami - Kobayashi J, Mitsui Y. Cyclin D1 inhibits cell proliferation through binding to PCNA and CDK2.

Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin - 1 in cervical cancer cells.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

MiR - 514a - 3p inhibits cell proliferation and epithelial - mesenchymal transition by targeting EGFR in clear cell renal cell carcinoma.

MicroRNA - 33b inhibits cell proliferation and glycolysis by targeting hypoxia - inducible factor - 1a in malignant melanoma.

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

In addition, RIPK2 inhibitor 1 appeared to also inhibit cell proliferation as determined by MTT assay, which did not appear to promote cell death.

Green tea reduces C - reactive protein and green tea catechins can successfully banish cancer cells, by slowing metastasis, inhibiting cell proliferation and inducing apoptosis.

Pomegranate's antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

Not exact matches

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

The researchers were able to inhibit proliferation of the cells in vitro using the FGFR inhibitors PD173074 and pazopanib.

Furthermore, they found that by inhibiting Akt they could significantly slow cell proliferation, cell migration and cell invasion in the lung cancer and bladder cancer cells.

In recent years it was also observed that it can function as a metabolic «signaler» that inhibits a biological pathway found in almost all higher life forms — the ability to sense when food has been eaten, energy is available and it's okay for cell proliferation, protein synthesis and growth to proceed.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

In summary, less Cdh1 prevents the normal function of APC / C, which eventually inhibits the degradation of PAX3, potentially leading to unregulated cell proliferation and cancer (melanoma in skin cell models).

Rapamycin works by inhibiting mTOR, which is involved in cell survival and proliferation.

This drug specifically inhibits BRAFV600E, a mutated protein that drives cancer cell proliferation.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

Palbociclib blocks a major alternate route, called the CDK4 / 6 growth signal, by inhibiting cancer cell proliferation and cellular division.

In fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cells.

In many cancers, CDKs are overactive or CDK - inhibiting proteins are not functional, which results in the unregulated proliferation of cancer cells.

One of his latest studies, published in 2015, found that exposure to bright blue - white light during the day has the opposite effect of light exposure at night: It greatly enhances the release of melatonin and inhibits the proliferation of prostate cancer cells in an animal model.

Previously MYC has been shown to promote proliferation and inhibit differentiation in dissociated cells in culture.

A recent paper in the experimental biology publication The FASEB Journal describes how peptides found in hookworms inhibit the proliferation of effector memory T cells, which, unlike regulatory T cells, can actually trigger inflammation.

The positively charged and neutral nanoparticles mildly inhibited stem cell proliferation but had no effect on their differentiation into bone cells.

This protein plays an essential role in the development of certain cancers, as it can activate or inhibit the proliferation of malignant cells.

The protein encoded by BRCA1 must in some way inhibit proliferation of cells in the breast, says Holt.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

In initial work with cell cultures in Petri dishes, the researchers methodically ruled out the possibility that HIV / gp120 would be inducing the death of stem cells and determined instead that HIV / gp120 was acting by inhibiting stem cell proliferation.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

«We show for the first time how HIV / AIDS inhibits proliferation of neural stem cells and prevents the formation of new nerve cells in the adult brain,» said Dr. Stuart Lipton, Director of Burnham's Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research.

Zhidan Tu, Yan Li, Dawn Smith, Nader Sheibani, Suber Huang, Timothy Kern and Feng Lin (2011): Retinal pericytes inhibit activated T cell proliferation Invest Ophthalmol Vis Sci.

MicroRNA -140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2.

Inhibit key enzymes in cancer cell specific metabolic pathways to disrupt tumor cell proliferation and survival

Effects of miR -145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.

MicroRNA - 24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin - a3 and regulating inflammatory responses.

MicroRNA - 138 inhibits hypoxia - induced proliferation of endothelial progenitor cells via inhibition of HIF - 1a - mediated MAPK and AKT signaling.

MicroRNA - 34a directly targets high - mobility group box 1 and inhibits the cancer cell proliferation, migration and invasion in cutaneous squamous cell carcinoma.

Wnt blockers inhibit the proliferation of lung cancer stem cells.

Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.

GCP, a genistein - rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines.

Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway.

MSCs impair the differentiation of monocytes or CD34 + HSCs into DCs by inhibiting the response of the former to maturation signals, reducing the expression of co-stimulatory molecules and hampering the ability of the former to stimulate naive T cell proliferation and IL - 12 secretion 33, 34, 35.

Hepatocyte growth factor promotes cell proliferation and inhibits progesterone secretion via PKA and MAPK pathways in a human granulosa cell line.