Sentences with phrase «inhibits cholesterol synthesis»

Well, it inhibits cholesterol synthesis; that's nice.

Not exact matches

Despite this possibility, mevinolin, the active ingredient in red yeast rice, is capable of reducing 7 - dehydrocholesterol levels, 22 and simvistatin (Zocor) not only inhibits the synthesis of mevalonate but also enhances the conversion of 7 - dehydrocholesterol to cholesterol by increasing the expression of 7 - DHCR.23 Simvistatin thereby hits the pool of 7 - dehydrocholesterol with a double - whammy, both decreasing its synthesis and increasing its degradation.

Needless to say the second group was hyperinsulinaemic and IR; insulin stimulates cholesterol synthesis and inhibits (re) absorption, while glucagon has the opposite effect; enterohepatic bile cycling is increased by glucagon.

This complex synthesis involves 37 steps and starts with a key enzyme known as HMG - CoA reductase (inhibited by statins, a class of cholesterol - lowering drugs).

Thus it makes sense, and helps to keep cholesterol in balance with requirements, that cholesterol synthesis is stimulated by insulin (the fed state hormone) and inhibited by glucagon (the fasting state hormone).

They also inhibit the cholesterol - producing enzyme HMG - CoA reductase in the liver, which lowers LDL, and in other cells (including the brain) which can produce both benefits and harms (for example, this enzyme is also needed to make vitamin K2, which is important for sulfatide synthesis in the brain and hence cognition).

Statins such as Lipitor, Zocor, Pavacol and Mevacor lower cholesterol by inhibiting HMG - CoA reductase, a key enzyme in cholesterol synthesis.