Further studies showed that Notch1 knockdown in NSCLC helps induce cell death (which
inhibits tumor initiation and growth); this process is mediated by p53, and thus the effects of inhibiting Notch1 require functional p53.
TGFβ
inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.
Not exact matches
The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin
tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and
inhibiting differentiation.