Research Paper Targeting intracellular MMPs efficiently
inhibits tumor metastasis and angiogenesis Yaqi Lv, Xiangmei Zhao, Lidan Zhu, Sijia Li, Qingqing Xiao, Wei He, Lifang Yin Theranostics 2018; 8 (10): 2830 - 2845.
Research Paper Long noncoding RNA miR503HG, a prognostic indicator,
inhibits tumor metastasis by regulating the HNRNPA2B1 / NF - κB pathway in hepatocellular carcinoma Hui Wang, Linhui Liang, Qiongzhu Dong, Lin Huan, Jia He, Botai Li, Chen Yang, Haojie Jin, Lin Wei, Chengtao Yu, Fangyu Zhao, Jinjun Li, Ming Yao, Wenxin Qin, Lunxiu Qin, Xianghuo He Theranostics 2018; 8 (10): 2814 - 2829.
Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or
inhibit tumor metastasis.
Not exact matches
His team's study found that
inhibiting CSN6 quickly destabilizes Myc, greatly impairing
metastasis and
tumor growth.
So a drug that blocks DDR2 from binding with collagen won't destroy the
tumor, but it could
inhibit the invasion of these
tumors into surrounding tissue and reduce
metastasis.
While research has supported AMD3100's ability to
inhibit tumor growth and
metastasis, the mechanism behind its effects on mesothelioma had not been determined.
Zhang, who earned an M.D. from the Peking University Health Science Center in China and a Ph.D. from the National University of Singapore, was recruited in 2007 to the Texas team that expected to see an increase of brain
metastasis when PTEN, a known
tumor -
inhibiting protein, was artificially deleted in a
tumor cell.
CXCR4 peptide antagonist
inhibits primary breast
tumor growth,
metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.
May 12, 2016 Stopping cancer in its tracks Researchers from the University of Chicago have shown that
inhibiting autophagy, a self - devouring process used by cells to degrade large intra-cellular cargo, effectively blocks
tumor cell migration and breast cancer
metastasis in
tumor models.
A CXCR4 antagonist CTCE - 9908
inhibits primary
tumor growth and
metastasis of breast cancer.
The Rac inhibitor EHop - 016
inhibits mammary
tumor growth and
metastasis in a nude mouse model.
The Rac inhibitor EHop - 016
Inhibits Mammary
Tumor Growth And
Metastasis In A Nude Mouse Model Translational Oncology PMID: 25389450 [PubMed] PMCID: PMC4225654.
5/7/2007 Targeting Sugar on Blood Vessels May
Inhibit Cancer Growth In a study that could point to novel therapies to prevent cancer spread, or
metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the
tumor.
In a follow - up study, one of the compounds — beta - escin, isolated from the seed of the Chinese horse chestnut —
inhibited tumor growth and
metastasis by 97 percent.
They
inhibit tumor blood vessel formation (angiogenesis) and
tumor cell migration (needed for
metastasis).
An understanding of mechanisms of
metastasis has led to the development of new treatments designed to delay or
inhibit tumor spread.