Liu, K.Q., Bunnell, S.C., Gurniak, C.B. & Berg, L.J. T cell receptor -
initiated calcium release is uncoupled from capacitative calcium entry in Itk - deficient T cells.
This regulation is spectacularly apparent in the exquisite speed and precision of synaptic exocytosis, where synaptotagmin (the
calcium - ion sensor for fusion) cooperates with complexin (the clamp activator) to control the precisely timed
release of neurotransmitters that
initiates synaptic transmission and underlies brain function.